{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:36:36Z","timestamp":1767990996350,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T00:00:00Z","timestamp":1733788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Predicting premature ventricular contraction (PVC) origin pre\u2010ablation is a fundamental step, as right ventricular outflow tract (RVOT) PVC often leads to higher success rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare nine published ECG criteria to differentiate between RVOT and non\u2010RVOT origins of PVCs and develop a stepwise algorithm using those criteria to better determine PVC origin to predict ablation success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two centers were involved in this study, the derivation group and the validation group. The derivation group included 65 patients with PVC left bundle branch block (LBBB) pattern morphology (predominantly negative in lead V<jats:sub>1<\/jats:sub>) and inferior axis (predominantly positive in leads II and III), who underwent ablation at Cipto Mangunkusumo Hospital (RSCM) (2017\u20132022). The validation group included 291 patients who underwent ablation at the Taipei Veteran General Hospital (2020\u20132023). We calculated and compared six diagnostic accuracy measures from nine previously published ECG morphology criteria to develop an algorithm to enhance the accuracy of predicting RVOT PVC origin for successful ablation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our multistep algorithm using Criteria 5, 8, and 1 enhanced diagnostic performance compared to using each criterion alone. The accuracy, sensitivity, and specificity in the derivation group were 86.2%, 93.6%, and 66.7%, respectively; those in the validation group were 85.9%, 90.8%, and 64.7%, respectively. The ROC curve AUCs were 0.802 and 0.775, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In cases of inferior axis and LBBB pattern PVCs, a multistep algorithm using multiple criteria increases the accuracy of predicting RVOT PVC origin instead of using a single criterion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.15118","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T08:50:25Z","timestamp":1733820625000},"page":"128-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multistep Algorithm to Predict RVOT PVC Site of Origin for Successful Ablation Using Available Criteria: A Two\u2010Center Cross\u2010Validation Study"],"prefix":"10.1111","volume":"48","author":[{"given":"Muhammad Rafdi","family":"Amadis","sequence":"first","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Wei","family":"Lo","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-7862","authenticated-orcid":false,"given":"Simon","family":"Salim","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine Dr. Cipto Mangunkusumo National General Hospital\u2013Faculty of Medicine Universitas Indonesia Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Yamin","sequence":"additional","affiliation":[{"name":"Cardiology Division, Department of Internal Medicine Dr. Cipto Mangunkusumo National General Hospital\u2013Faculty of Medicine Universitas Indonesia Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-1052","authenticated-orcid":false,"given":"Yenn\u2010Jiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Cardiovascular Center Taichung Veterans General Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6722-1826","authenticated-orcid":false,"given":"Shih\u2010Lin","family":"Chang","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5715-2070","authenticated-orcid":false,"given":"Yu\u2010Feng","family":"Hu","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fa\u2010Po","family":"Chung","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubiana","family":"Sukardi","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology Integrated Cardiocerebrovascular Service. Dr. Cipto Mangunkusumo National General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin\u2010Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting\u2010Yung","family":"Chang","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"},{"name":"Department of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Kuo","sequence":"additional","affiliation":[{"name":"Heart Rhythm Center Division of Cardiology Department of Medicine Taipei Veterans General Hospital Taipei 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