{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:59:12Z","timestamp":1767650352761,"version":"3.40.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T00:00:00Z","timestamp":1737936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Globally, the number of cardiac implantable electronic devices (CIEDs) is increasing. In our study, we aimed to investigate whether CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc and R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc scores are predictive of CIED\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our investigation was carried out with a multicenter retrospective design. Patients who underwent CIED surgery at two cardiac centers in Turkey between January 2011 and May 2023, 1676, were evaluated. The patients were divided into two groups according to their R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc scores. Patients with R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc \u2265 5 were included in group 1 (380 patients), and patients with R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc &lt; 5 (1296 patients) were included in group 2. The primary outcome was defined as the cumulative events. Each component of cumulative events, such as hematoma, pericardial effusion, pneumothorax, and infection, was also defined as a secondary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study's patient population had an average age of 62.9 \u00b1 14 years. Pneumothorax (1.8%\u00a0vs. 1.3%, <jats:italic>p<\/jats:italic> = 0.444), pericardial effusion or tamponade (0.35%\u00a0vs. 0.2%, <jats:italic>p<\/jats:italic> = 0.659), and clinically significant hematoma (1.1%\u00a0vs. 0.6%, <jats:italic>p<\/jats:italic> = 0.376) were comparable between the groups. Infection\u2010related devices and cumulative events classified as primary outcomes were higher in the R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc \u2265 5 group (6.1%\u00a0vs. 1.2%, <jats:italic>p<\/jats:italic> &lt; 0.001; 7.6%\u00a0vs. 3.2%, <jats:italic>p<\/jats:italic> &lt; 0.001, respectively). Modeling analyses showed that the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score and HT were also independent predictors of device\u2010related infection and cumulative events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc \u2265 5 groups, infection related to the device system and cumulative events were higher. Patients with an R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score of 5 or more and a high CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc score should be evaluated more carefully regarding infection and cumulative events before and after the operation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.15148","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T14:44:53Z","timestamp":1737989093000},"page":"151-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ability of CHA2DS2\u2010VASc\/R2CHA2DS2\u2010VASc Scores to Predict Complications Related to Cardiac Implantable Electronic Devices"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2807-6424","authenticated-orcid":false,"given":"Serdar","family":"S\u00f6ner","sequence":"first","affiliation":[{"name":"Department of Cardiology Health 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Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Metin","family":"Ok\u015ful","sequence":"additional","affiliation":[{"name":"Department of Cardiology Health Science University, Gazi Ya\u015fargil Training and Research Hospital  Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan Duha","family":"C\u00f6mert","sequence":"additional","affiliation":[{"name":"Department of Cardiology Health Science University, Gazi Ya\u015fargil Training and Research Hospital  Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Sait","family":"Co\u015fkun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ergani State Hospital  Diyarbak\u0131r Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fclya Tosun","family":"S\u00f6ner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Reanimation Health Science 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