{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:32:59Z","timestamp":1790091179930,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periprocedural electrophysiological (EP) testing may be useful to predict high degree atrioventricular block (HAVB) risk in patients undergoing transcatheter aortic valve replacement (TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether pre\u2010 and immediate post\u2010TAVR ECG and HV interval findings are predictive of HAVB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive TAVR patients without prior pacemaker (PM) implantation underwent ECG and standardized HV interval measurements pre\u2010 and post\u2010TAVR using the quadripolar catheter for rapid pacing. The primary outcome was HAVB &gt;24 h after TAVR or ventricular pacing need<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 97 included patients, 8 experienced the primary outcome (7 with HAVB and 1 with PM need). On univariate analysis, pre\u2010 and post\u2010TAVR PR, post\u2010TAVR HV, and Delta\u2010HV intervals were predictors of the primary outcome. A Delta\u2010HV interval \u226518\u00a0ms predicted HAVB with sensitivity = 50% and specificity = 90% (AUC = 0.708, PPV = 31%), while an HV interval \u226560\u00a0ms after TAVR had sensitivity = 63% and specificity = 79% (AUC = 0.681, PPV = 21%). None of the patients with a PR interval \u2264180\u00a0ms post\u2010TAVR experienced the primary outcome. Among patients with new\u2010onset LBBB, an HV interval post\u2010TAVR &gt;65\u00a0ms was the only predictor of HAVB (AUC = 0.776, PPV = 33%, and NPV = 97%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The yield of periprocedural EP assessment during TAVR is limited considering that about half of the at\u2010risk patients fail to be identified. However, early periprocedural risk stratification may be more useful in the subset of patients with new\u2010onset LBBB. Among ECG findings, a post\u2010TAVR PR interval \u2264180\u00a0ms identifies a subgroup at very low risk, independently of QRS interval and morphology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pace.15159","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T16:16:02Z","timestamp":1738858562000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Role of Routine Electrophysiological Study Performed During Transcatheter Aortic Valve Replacement to Predict AV Block"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0063-8648","authenticated-orcid":false,"given":"Mattia","family":"Pagnoni","sequence":"first","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Meier","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0040-8191","authenticated-orcid":false,"given":"Adrian","family":"Luca","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Fournier","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhang","family":"Aminfar","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christelle","family":"Haddad","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"},{"name":"Arrhythmias Unit, Louis Pradel Cardiovascular Hospital Hospices Civils de Lyon  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccolo","family":"Maurizi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Domenichini","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Le Bloa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Herrera Siklody","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Teres","sequence":"additional","affiliation":[{"name":"Department of Cardiology Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Cook","sequence":"additional","affiliation":[{"name":"Department of Cardiology Clinique Cecil, Hirslanden Group  Lausanne Switzerland"},{"name":"Department of Cardiology University &amp; 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