{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:22:47Z","timestamp":1792686167041,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3601300"],"award-info":[{"award-number":["2022YFC3601300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) and atrial flutter (AFL) represent increasingly significant health burden globally. We aimed to systematically evaluate the status and trends of AF\/AFL burden and attributable risk factors in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed the burden of AF\/AFL measured as prevalence, incidence, mortality, and disability\u2010adjusted life years (DALYs), by sex and age groups in China based on the Global Burden of Diseases Study (GBD) 2021 project.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In China, there were 10,775.72 thousand AF\/AFL prevalent cases, 916.18 thousand AF\/AFL incident cases, and 64.73 thousand AF\/AFL mortality cases, contributing to 1653.12 thousand DALYs due to AF\/AFL in 2021. Trend analysis indicated that the AAPC of number and crude rates of prevalence, incidence, mortality, and DALYs all escalated from 1990 to 2021. The current AF\/AFL burden and temporal trend between 1990 and 2021 displayed heterogeneity based on sex and age groups. The spectrum for risk factors attributed for DALYs due to AF\/AFL presented sex\u2010 and age\u2010specific manifestation. High systolic blood pressure served as the emerging leading contributor to DALYs due to AF\/AFL in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A significant increase in the burden of AF\/AFL underscores the enduring public health burden of AF\/AFL in China, marked by profound sex and age\u2010related variations. There is a pressing imperative to adopt tailored strategies to attenuate increasing burden of AF\/AFL and combat alongside high complication burden due to AF\/AFL in China.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.15175","type":"journal-article","created":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T11:49:03Z","timestamp":1741866543000},"page":"447-454","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Burden of Atrial Fibrillation and Atrial Flutter From 1990 to 2021 in China: Global Burden of Disease Study 2021 Update"],"prefix":"10.1111","volume":"48","author":[{"given":"Xiangyi","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University National Clinical Research Center for Cardiovascular Diseases  Beijing 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