{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T18:33:13Z","timestamp":1773945193278,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although radiofrequency ablation is effective for treating left ventricular papillary muscle (PM) arrhythmias, procedural complications like catheter entrapment and risk of PM injury are incompletely understood. Furthermore, cardiac catheters lack tensile force monitoring at the catheter tip, creating procedural blind spots that prevent the detection and potential mitigation of such complications. Therefore, this study aimed to evaluate the force required to rupture PMs before and after ablation, providing insights into procedural safety and potential risks associated with PM ablation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty\u2010six samples were excised from fresh porcine hearts. Samples were divided equally into control and ablated groups. Ablations were performed at 50\u00a0W, 60\u00a0s, and 30\u00a0g. All samples underwent tensile testing until failure. The mean ultimate tensile strength (UTS) was compared between groups, and each sample underwent histological analysis to examine the failure site and ablative structural changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ablated group had a lower mean UTS than the control group, but this difference was not significant. The ablated group had the only samples to fail at less than physiological systole peak force (6\u00a0N). The ablated samples had myocyte necrosis and denaturation of collagen fibers in the chordae tendineae (CT). Both groups had myocardial tearing inferior to the insertion point instead of at the PM\u2010CT junction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RF ablations at the PM create changes in the structure of the PM\u2010CT junction that could raise procedural concerns. Future work will explore in vivo tensile testing, more varied ablation conditions, and any associated fibrotic healing that could affect clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70001","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:04:16Z","timestamp":1762772656000},"page":"90-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Uncovering the Structural Effects of Radiofrequency Ablation on the Papillary Muscle\u2013Chordae Tendineae Junction"],"prefix":"10.1111","volume":"49","author":[{"given":"Drew","family":"Bernard","sequence":"first","affiliation":[{"name":"Electrophysiology Clinical Research and Innovations The Texas Heart Institute at Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Hector","family":"Victor","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Cao","sequence":"additional","affiliation":[{"name":"Electrophysiology Clinical Research and Innovations The Texas Heart Institute at Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skylar","family":"Buchan","sequence":"additional","affiliation":[{"name":"Electrophysiology Clinical Research and Innovations The Texas Heart Institute at Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathews","family":"John","sequence":"additional","affiliation":[{"name":"Electrophysiology Clinical Research and Innovations The Texas Heart Institute at Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payam","family":"Safavi\u2010Naeini","sequence":"additional","affiliation":[{"name":"Electrophysiology Clinical Research and Innovations The Texas Heart Institute at Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Post","sequence":"additional","affiliation":[{"name":"Electrophysiology Clinical Research and Innovations The Texas Heart Institute at Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Vela","sequence":"additional","affiliation":[{"name":"Cardiovascular Pathology Research The Texas Heart Institute at Baylor College of Medicine Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Jane","family":"Grande\u2010Allen","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Rice University  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7176-5586","authenticated-orcid":false,"given":"Mehdi","family":"Razavi","sequence":"additional","affiliation":[{"name":"Electrophysiology Clinical Research and Innovations The Texas Heart Institute at Baylor College of Medicine Houston Texas USA"},{"name":"Division of Cardiology Department of Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.04.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.06.026"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i20.5556"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15103"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.08.005"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02206.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2014.12.011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.115.003874"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12439"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.07.062"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2010.07.013"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2017.01.003"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.6.2667"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14462"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2022.07.025"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.06.151"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.09.028"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2009.01594.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.958280"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioelechem.2021.107871"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2025.01.013"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.012734"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.10.067"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15813"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307291"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.04.019"},{"key":"e_1_2_11_28_1","first-page":"644","article-title":"Failure Mechanics of Mitral Valve Chordae Tendineae","volume":"11","author":"Sedransk K. 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