{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T20:37:56Z","timestamp":1775939876667,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cardiac resynchronization therapy (CRT) may affect the patients\u2019 psychological status differently in various populations. There are limited data regarding depression and anxiety in this setting, while there are no data regarding Greek patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We studied heart failure with reduced ejection fraction (HFrEF) patients, without conditions affecting psychological status, undergoing CRT. We used the Minnesota Living with Heart Failure Questionnaire (MLHFQ), the 9\u2010item Patient Health Questionnaire (PHQ\u20109), and the 7\u2010item Generalized Anxiety Disorder Scale (GAD\u20107) at baseline and 6\u2010 and 12\u2010month postimplantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After excluding seven patients who experienced defibrillator shocks, we analyzed 99 patients (median age: 72 years, 77% men). The baseline MLHFQ score was 37 (interquartile range [IQR]: 36); at 6 months, 1 (IQR: 8); and at 12 months, 0.5 (IQR: 10);\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01. The baseline PHQ\u20109 score was 9 (IQR: 11); at 6 months, 0 (IQR: 2); and at 12 months, 0 (IQR: 2);\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01. The baseline GAD\u20107 score was 8 (IQR: 16); at 6 months, 0 (IQR: 1.5); and at 12 months, 0 (IQR: 3);\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.01. At baseline, 44% of patients had clinically significant depression (PHQ\u20109 score \u226510), and 45% clinically significant anxiety (GAD\u20107 score \u226510). The baseline PHQ\u20109 and GAD\u20107 scores correlated with the MLHFQ score. The logistic regression analysis revealed that clinically substantial depression at baseline (PHQ\u20109 \u2265 10) had a negative association with chronic kidney disease [OR: 0.55;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.01].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Depression and anxiety markedly improved during the 12\u2010month follow\u2010up period after CRT device implantation in HFrEF patients who did not receive shock therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70002","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T06:34:09Z","timestamp":1750833249000},"page":"925-931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Depression and Anxiety in Patients Who Received a CRT Device and Did Not Have Shock Therapy During a 12\u2010Month Follow\u2010Up"],"prefix":"10.1111","volume":"48","author":[{"given":"Elizabeth","family":"Florou","sequence":"first","affiliation":[{"name":"First Department of Cardiology University of Ioannina Medical School  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Sfairopoulos","sequence":"additional","affiliation":[{"name":"First Department of Cardiology University of Ioannina Medical School  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sofia","family":"Plakoutsi","sequence":"additional","affiliation":[{"name":"First Department of Cardiology University of Ioannina Medical School  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aris","family":"Bechlioulis","sequence":"additional","affiliation":[{"name":"Second Department of Cardiology University of Ioannina Medical School  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Zekios","sequence":"additional","affiliation":[{"name":"First Department of Cardiology University of Ioannina Medical School  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haralampos","family":"Milionis","sequence":"additional","affiliation":[{"name":"First Division of Internal Medicine University of Ioannina Medical School  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Skapinakis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Ioannina Medical School  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panagiotis","family":"Korantzopoulos","sequence":"additional","affiliation":[{"name":"First Department of Cardiology University of Ioannina Medical School  Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1136\/heartjnl-2016-310656","article-title":"Cardiac Resynchronisation Therapy: Current Indications, Management and Basic Troubleshooting","volume":"103","author":"Rao P.","year":"2017","journal-title":"Heart"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2021.10.021"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.070105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-41967-7_21"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2016.1151327"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2021.07.011"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.19102\/icrm.2022.130805"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000162"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1865"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.101987"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.26599\/1671-5411.2025.02.003"},{"key":"e_1_2_12_13_1","first-page":"10","article-title":"Translation and Validation of the Greek \u201cMinnesota Living With Heart Failure\u201d Questionnaire","volume":"56","author":"Brokalaki H.","year":"2015","journal-title":"Hellenic Journal of Cardiology"},{"key":"e_1_2_12_14_1","unstructured":"The Patient Health Questionnaire (PHQ) Screeners.Greek version of PHQ\u20109. (2020) https:\/\/www.phqscreeners.com\/images\/sites\/g\/files\/g10060481\/f\/201412\/PHQ9_Greek%20for%20Greece.pdf."},{"key":"e_1_2_12_15_1","unstructured":"The Patient Health Questionnaire (PHQ) Screeners.The Greek version of GAD\u20107. (2020) https:\/\/www.phqscreeners.com\/images\/sites\/g\/files\/g10060481\/f\/201412\/GAD7_Greek%20for%20Greece.pdf."},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00821"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/3158954"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux342"},{"key":"e_1_2_12_19_1","first-page":"1865","article-title":"Quality of Life Predicting Long\u2010Term Outcomes in Cardiac Resynchronization Therapy Patients","volume":"21","author":"Nagy K. V.","year":"2019","journal-title":"Europace"},{"key":"e_1_2_12_20_1","first-page":"26","article-title":"Factors Associated With Depression and Anxiety of Hospitalized Patients With Heart Failure","volume":"56","author":"Polikandrioti M.","year":"2015","journal-title":"Hellenic Journal of Cardiology"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apnr.2017.01.003"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus168"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz018"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eun073"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13416"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.11.006"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-013-0372-8"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv005"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12361"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.12257"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:03:39Z","timestamp":1773054219000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,25]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/pace.70002"],"URL":"https:\/\/doi.org\/10.1111\/pace.70002","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,25]]},"assertion":[{"value":"2025-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}