{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:40:07Z","timestamp":1791214807815,"version":"4.1.0"},"reference-count":8,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T00:00:00Z","timestamp":1755388800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cardiac resynchronization therapy (CRT) has been widely used in adult patients with heart failure and ventricular dyssynchrony, but its application in pediatric patients with congenital heart disease (CHD), particularly those with single\u2010ventricle physiology, remains limited. We report the case of a male patient with congenitally corrected transposition of the great arteries (cc\u2010TGA) and single\u2010ventricle physiology who developed complete atrioventricular block and underwent single\u2010chamber epicardial pacing at the age of four. A dual\u2010chamber pacemaker was later implanted at the time of Glenn surgery. By age 12, in the pre\u2010Fontan period, the patient showed signs of systemic ventricular dysfunction and electromechanical dyssynchrony, including a QRS duration of 167\u00a0ms, reduced left ventricular ejection fraction (35%\u201340%), and elevated NT\u2010proBNP (1507 pg\/mL). CRT upgrade was performed simultaneously with extracardiac Fontan completion. Postoperative improvement was significant, with QRS narrowing to 130\u00a0ms, normalization of ventricular function (EF: 50%), and NT\u2010proBNP reduction to 146 pg\/mL. This case illustrates the feasibility and potential benefits of CRT in patients with single\u2010ventricle physiology, particularly when timed strategically with Fontan completion. It also supports emerging guideline recommendations for CRT use in systemic single\u2010ventricle patients with symptomatic heart failure despite medical therapy.<\/jats:p>","DOI":"10.1111\/pace.70030","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:26:21Z","timestamp":1755498381000},"page":"1114-1118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiac Resynchronization Therapy in Single\u2010Ventricle Physiology: A Case Report of cc\u2010TGA Managed With Fontan Strategy"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9043-9687","authenticated-orcid":false,"given":"Merve Maze","family":"Aydemir","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology University of Health Sciences Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4355-8587","authenticated-orcid":false,"given":"Mustafa","family":"Nalbant","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology University of Health Sciences Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Canda\u015f","family":"Kafal\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology University of Health Sciences Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Sevin\u00e7","family":"\u015eeng\u00fcl","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology University of Health Sciences Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celal","family":"Akdeniz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology University of Health Sciences Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okan","family":"Y\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiovascular Surgery University of Health Sciences Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-020-00863-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2020.09.018"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.14376"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12872"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjcpc.2022.01.004"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2018.07.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2024.09"},{"issue":"3","key":"e_1_2_9_9_1","first-page":"1","article-title":"Conduction System Pacing in Pediatric and Congenital Heart Disease","volume":"14","author":"Chubb H.","year":"2023","journal-title":"Frontiers in Physiology"}],"container-title":["Pacing and Clinical 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