{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T02:24:46Z","timestamp":1775183086113,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n S wave in lead V\n 5\/6<\/jats:sub>\n has been reported as a marker indicated for successful left bundle branch (LBB) capture. This study aimed to evaluate the value of the S wave in lead V\n 5\/6<\/jats:sub>\n in predicting the long\u2010term clinical outcomes in heart failure (HF) patients treated with left bundle area pacing (LBBAP).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Consecutive HF patients receiving LBBAP were prospectively enrolled and followed at least 2 years. ECG were analyzed to identify the S wave in lead V\n 5\/6<\/jats:sub>\n . The composite end point was all\u2010cause mortality, HF hospitalization, and malignant ventricular arrhythmias. Non\u2010response to LBBAP delivered cardiac resynchronization therapy (CRT) was defined as left ventricular ejection fraction improvement <5% at 6 months after implantation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 57 patients were included with the mean age of 59.90\u00a0\u00b1\u00a012.57 years and 39 (68.42%) males. S wave in V\n 5\/6<\/jats:sub>\n was observed in 38 patients. During a mean follow up of 29.84\u00a0\u00b1\u00a012.51 months, Kaplan\u2013Meier curves showed a 77.8% reduction in risk of composite end point for V\n 5\/6<\/jats:sub>\n with S (HR 0.222; 95% CI 0.065, 0.756; log\u2010rank,\n p\u00a0<\/jats:italic>\n =\u00a00.0069). Multivariate Cox regression analysis revealed that V\n 5\/6<\/jats:sub>\n with S was associated with a lower risk of the composite end point by 69.0% (adjusted HR 0.31; 95% CI 0.09, 1.05;\n p\u00a0<\/jats:italic>\n =\u00a00.041). The non\u2010response rate of LBBAP was 22.58% in V\n 5\/6<\/jats:sub>\n with S and 58.82% in V\n 5\/6<\/jats:sub>\n without S (\n p\u00a0<\/jats:italic>\n =\u00a00.012).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n S wave in lead V\n 5<\/jats:sub>\n and\/or V\n 6<\/jats:sub>\n after LBBAP predicts better clinical outcomes, and has a better response rate of LBBAP for CRT in HF patients.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pace.70031","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T15:40:08Z","timestamp":1756136408000},"page":"1077-1085","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Postoperative S Wave in Lead V\n 5<\/sub>\n and\/or V\n 6<\/sub>\n Predicts Better Clinical Outcomes in Heart Failure Patients With Left Bundle Branch Area Pacing"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2784-2721","authenticated-orcid":false,"given":"Kailun","family":"Zhu","sequence":"first","affiliation":[{"name":"Cardiac Arrhythmia Center Fuwai Hospital National Center for Cardiovascular Diseases Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"He","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center Fuwai Hospital National Center for Cardiovascular Diseases Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haojie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center Fuwai Hospital National Center for Cardiovascular Diseases Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuangshi","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases Fuwai Hospital National Center for Cardiovascular Diseases Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofei","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center Fuwai Hospital National Center for Cardiovascular Diseases Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2325-3839","authenticated-orcid":false,"given":"Xiaohan","family":"Fan","sequence":"additional","affiliation":[{"name":"Cardiac Arrhythmia Center Fuwai Hospital National Center for Cardiovascular Diseases Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.07.019"},{"issue":"12","key":"e_1_2_8_3_1","first-page":"2628","article-title":"His\u2010Purkinje Conduction System Pacing Optimized Trial of Cardiac Resynchronization Therapy vs Biventricular Pacing: HOT\u2010CRT Clinical Trial","volume":"9","author":"Vijayaraman P.","year":"2023","journal-title":"Journal of the American College of Cardiology: Clinical Electrophysiology"},{"issue":"2","key":"e_1_2_8_4_1","first-page":"295","article-title":"Left Bundle Branch Pacing vs Left Ventricular Septal Pacing vs Biventricular Pacing for Cardiac Resynchronization Therapy","volume":"10","author":"Diaz J. C.","year":"2024","journal-title":"Journal of the American College of Cardiology: Clinical Electrophysiology"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.03.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.15077"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"108","article-title":"Outcomes of Upgrading to LBBP in CRT Nonresponders: A Prospective, Multicenter, Nonrandomized, Case\u2010Control Study","volume":"10","author":"Chen X.","year":"2024","journal-title":"Journal of the American College of Cardiology: Clinical Electrophysiology"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.12.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.09.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14382"},{"issue":"11","key":"e_1_2_8_11_1","first-page":"2471","article-title":"Transseptal Transition Patterns During Left Bundle Branch Area Lead Implantation","volume":"10","author":"Jastrz\u0119bski M.","year":"2024","journal-title":"Journal of the American College of Cardiology: Clinical Electrophysiology"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"issue":"9","key":"e_1_2_8_13_1","first-page":"1166","article-title":"Evaluation of the Criteria to Distinguish Left Bundle Branch Pacing From Left Ventricular Septal Pacing","volume":"7","author":"Wu S.","year":"2021","journal-title":"Journal of the American College of Cardiology: Clinical Electrophysiology"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513614"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14874"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14854"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/13814788.2019.1639667"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.09.018"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.10.062"},{"issue":"5","key":"e_1_2_8_20_1","first-page":"587","article-title":"Reaching the Left Bundle Branch Pacing Area Within 36 Heartbeats","volume":"79","author":"Jastrz\u0119bski M.","year":"2021","journal-title":"Kardiologia Polska"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2022.03.003"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:08:19Z","timestamp":1773644899000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/pace.70031"],"URL":"https:\/\/doi.org\/10.1111\/pace.70031","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,25]]},"assertion":[{"value":"2025-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}