{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:52:50Z","timestamp":1773647570479,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T00:00:00Z","timestamp":1756080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Premature ventricular complexes (PVC) are a common phenomenon observed in both normal and pathological heart conditions. However, they do not always behave in the same way. Different PVCs present with varying QRS morphologies, mechanisms, and origin sites. These differences may imply distinct prognoses. To date, the impact of the three\u2010dimensional distribution of PVCs across the heart on the prognosis of ICD recipients has not been adequately investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We conducted an ambidirectional cohort study. Patients underwent two twelve\u2010lead ambulatory ECG recordings during follow\u2010up. The spatial distribution of PVCs was analyzed using the algorithm proposed by Kuchar et\u00a0al. The impact of this spatial distribution on clinical variables was assessed using mixed generalized models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010five patients were enrolled, with a mean follow\u2010up time of 41.12 \u00b1 13.48 months. All patients underwent two 12\u2010lead ambulatory ECG recordings. The median PVC count was 91.5. PVCs were classified according to the algorithm proposed by Kuchar et\u00a0al. PVCs arising from exit sites located in the intermediate left ventricle were associated with a higher number of therapies (odds ratio [OR]: 4.78; 95% confidence interval [CI], 1.19\u201319.26;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.028) and prolonged QRS duration. PVCs with exit sites located in the septal region were associated with higher NYHA functional classes (OR: 2.22 [95% CI: 1.08\u20134.44];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030). No statistically significant interaction was found between PVC topography and gender, number of ATP episodes, ATP success rate, or number of shock episodes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The spatial distribution of PVCs influenced the prognosis of ICD recipients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70033","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T15:46:35Z","timestamp":1756136795000},"page":"1157-1166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of the Spatial Distribution of Ventricular Extrasystoles on Implantable Cardioverter\u2010Defibrillator Recipients"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7253-2635","authenticated-orcid":false,"given":"Carlos Arthur Hansel Diniz da","family":"Costa","sequence":"first","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Menichelli Medeiros","family":"Coelho","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhanniel Theodorus Helhyas Oliveira Shilva Gomes","family":"Villar","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Rodrigues de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Henrique Correia","family":"Filgueiras","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enia Lucia","family":"Coutinho","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Cirenza","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo Amato Vincenzo","family":"de Paola","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,25]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102016\u2010309632"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.45.6.717"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198501243120401"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198908103210629"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108167.2011.02021.x"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.13067"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0735\u20101097(89)90232\u20105"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.77.4.759"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540\u20108167.2007.00721.x"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.611640"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109149(81)90606\u20108"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002\u20109149(84)90209\u20101"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000145610.64014.e4"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13333"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.36660\/abc.20230337i"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.3169"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022\u20100736(75)80050\u20101"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl\u20102019\u2010316105"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840\u2010007\u20109157\u20102"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11236889"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.018960"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.059"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/circep.115.002847"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70033","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70033","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70033","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:08:16Z","timestamp":1773644896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,25]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/pace.70033"],"URL":"https:\/\/doi.org\/10.1111\/pace.70033","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,25]]},"assertion":[{"value":"2025-05-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}