{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:09:28Z","timestamp":1790431768661,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:00:00Z","timestamp":1758585600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) ablation often involves large\u2010diameter catheters, posing challenges for post\u2010procedure hemostasis and discharge. The impact of Perclose Prostyle vascular closure device (VCD) on time to ambulation and vascular access complications in patients undergoing pulsed field ablation (PFA) is uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients undergoing PFA for AF with 16.8 French (F) sheaths were randomly assigned in a 1:1 ratio to Prostyle (Abbott Vascular, USA) or standard closure with a figure\u2010of\u2010eight suture (FO8) at a single center in an open\u2010label design. A maximum of three VCDs were allowed. Pre\u2010closure was achieved with deployment at 2 and 10 o'clock positions and a final Prostyle secured the second 6F short sheath. Ultrasound guidance was used in all patients. The primary end point was time to ambulation post\u2010procedure. Secondary end points included major and minor periprocedural adverse events. Follow\u2010up occurred up to 2 weeks post\u2010procedure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixty patients were randomized to undergo VCD (30 patients) or F08 suture (30 patients). There were no significant differences in baseline characteristics between groups. Time to ambulation was significantly reduced (215 \u00b1 113 min) in the VCD group compared with the FO8 group (338 \u00b1 71 min;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). There were no major peri\u2010procedural adverse events in either group. Rate of minor bleeding was significantly increased in the FO8 group (27%; 8\/30) compared with none in the VCD group ((0%; 0\/30; p = 0.005)). Rate of manual compression was numerically higher in the FO8 group (33%; 10\/30) compared with the VCD group (10%; 3\/30;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.057). There were no differences in acute pain score, confidence in walking, overall patient satisfaction, or overall nurse satisfaction between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this randomized controlled trial, VCD with Prostyle reduced time to ambulation and reduced minor bleeding in patients undergoing PFA for AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70051","type":"journal-article","created":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T11:40:51Z","timestamp":1758627651000},"page":"1294-1300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vascular Closure Device Following Pulsed Field Ablation for Atrial Fibrillation: A Randomized Controlled Trial"],"prefix":"10.1111","volume":"48","author":[{"given":"Alexander","family":"Dashwood","sequence":"first","affiliation":[{"name":"Victorian Heart Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3206-5725","authenticated-orcid":false,"given":"Francis J.","family":"Ha","sequence":"additional","affiliation":[{"name":"Victorian Heart Hospital  Melbourne Australia"},{"name":"Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Healy","sequence":"additional","affiliation":[{"name":"Victorian Heart Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Puchalski","sequence":"additional","affiliation":[{"name":"The Cardiac Centre  Gold Coast Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sing Huey","family":"Cheng","sequence":"additional","affiliation":[{"name":"Victorian Heart Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Tian","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Kotschet","sequence":"additional","affiliation":[{"name":"Victorian Heart Hospital  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.03.418"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaf085.487"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-021-00981-5"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14753"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.08.013"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1253\/circrep.CR-24-0045"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16440"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae200"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2016.09.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.125.013719"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16345"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-024-01773-3"},{"key":"e_1_2_10_16_1","article-title":"Intraprocedural Activated Clotting Time and Heparin Dosage in Pulsed Field Ablation of Paroxysmal Atrial Fibrillation","volume":"12","author":"Ma C.","year":"2025","journal-title":"Frontiers in Cardiovascular Medicine [Internet]"},{"issue":"5","key":"e_1_2_10_17_1","first-page":"393","article-title":"Cryoballoon or Radiofrequency Ablation for Paroxysmal Atrial Fibrillation","volume":"36","author":"Kuck K. H.","year":"2016","journal-title":"Journal of Cardiopulmonary Rehabilitation and Prevention [Internet]"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2029980"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.10.037"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70051","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70051","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70051","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:08:39Z","timestamp":1773644919000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,23]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/pace.70051"],"URL":"https:\/\/doi.org\/10.1111\/pace.70051","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,23]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}