{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:05:46Z","timestamp":1782511546366,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Predicting recurrence after radiofrequency catheter ablation (RFCA) in persistent atrial fibrillation (PeAF) remains challenging. This study evaluated the predictive value of F\u2010wave amplitude (FWA), F\u2010wave duration (FWD) in inferior ECG leads (II, III, aVF), and AF duration for post\u2010ablation recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this dual\u2010center retrospective study, 763 persistent atrial fibrillation (PeAF) patients undergoing first RFCA (2017\u20132022) were analyzed. Pre\u2010procedural FWA and FWD were measured across 12\u2010lead ECGs using MATLAB. Clinical data and 12\u2010month follow\u2010up outcomes were collected. Independent predictors were identified via binary logistic regression, and a gradient boosting machine (GBM) model was developed. Model performance was assessed using ROC curves, calibration plots, and decision curve analysis (DCA), with internal (random split) and external (between\u2010center) validation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At 12 months, 198 patients (26%) experienced recurrence. Recurrence patients exhibited significantly lower inferior lead FWA (0.108 [0.076\u20130.157] vs. 0.126 [0.087\u20130.173] mV,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003), narrower FWD (54.96 [40.26\u201371.31] vs. 61.46 [42.7\u201376] ms,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.038), and longer AF duration (13.8 [4\u201338] vs. 6.5 [3\u201321] months,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). Multivariate analysis identified inferior lead FWA (OR = 0.788, 95%CI 0.662\u20130.937,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007) and AF duration (OR = 1.014, 95%CI 1.007\u20131.021,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) as independent predictors. The model combining AF duration and FWA achieved an AUC of 0.692 (95%CI 0.648\u20130.737), improving to 0.746 (0.701\u20130.787) with FWD inclusion. Validation demonstrated stable discrimination (internal AUC = 0.722, 95%CI 0.680\u20130.762; external AUC = 0.703, 0.659\u20130.747).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Inferior lead FWA and AF duration are independent predictors of post\u2010RFCA recurrence in persistent AF. The combined model integrating these parameters with FWD shows robust discriminative ability and clinical utility, supporting personalized treatment strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70064","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:43:53Z","timestamp":1760107433000},"page":"1320-1330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Combined F\u2010wave and AF Duration Predict Post\u2010Ablation Recurrence in Persistent AF: Dual\u2010Center Study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3294-5965","authenticated-orcid":false,"given":"Yuanyuan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-9703","authenticated-orcid":false,"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University Jiangsu Provincial People's Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haozhe","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arsh","family":"Rehman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juefei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Bin","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University Jiangsu Provincial People's Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanjing Medical University Jiangsu Provincial People's Hospital  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuegang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, State Key Laboratory of Organ Failure Research Nanfang Hospital, Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.946"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00820-8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43283-7"},{"issue":"09","key":"e_1_2_9_6_1","first-page":"787","article-title":"Research Progress on Imaging Examination for Predicting Atrial Fibrillation Recurrence After Radiofrequency Ablation","volume":"21","author":"Zhou J.","year":"2023","journal-title":"Chinese Journal of Cardiovascular 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Success Rate in Patients With Long\u2010Standing Persistent Atrial Fibrillation","volume":"35","author":"Cai H. 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