{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:27:48Z","timestamp":1789428468929,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T00:00:00Z","timestamp":1760659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Vein of Marshall ethanol infusion (VOM\u2010EI) in patients with Atrial Fibrillation (AFib) triggers local injury, which may increase the subsequent radiofrequency catheter ablation (RFCA) success rate in persistent atrial fibrillation (PeAF). The long\u2010term durability of VOM\u2010EI induced low\u2010voltage area (LVA), might condition the success of RFCA after VOM\u2010EI. We hypothesized that the amount of LVA after VOM\u2010EI decreases over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with recurrent PeAF and no history of previous ablation were enrolled in this prospective, center\u2010cluster, case\u2010control study. In the experimental group, RFCA was performed 1 month after VOM\u2010EI. In the control group, VOM\u2010EI and RFCA were performed concomitantly. The primary endpoint was the bipolar VOM\u2010EI LVA measured immediately prior to RFCA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We studied 80 consecutive patients who met the inclusion criteria. The two groups did not differ in baseline characteristics. The mean bipolar VOM\u2010EI\u2010LVA measured before RFCA was significantly smaller in the 40 patients who underwent VOM\u2010EI 1 month earlier than in the group of 40 patients who underwent the standard procedure (2.6\u00a0\u00b1\u00a02.4 vs. 10.0\u00a0\u00b1\u00a07.0 cm\n                      <jats:sup>2<\/jats:sup>\n                      ,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012). At a mean follow\u2010up of 19.6\u00a0\u00b1\u00a07.3 months, freedom from AF\/AT recurrences was promisingly higher in the investigational group compared to the control group (90.0% vs. 82.5%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data suggest that the endocardial newly\u2010formed lesion induced by VOM\u2010EI decreases over time, probably due to progressive resolution of perilesional oedema. These results merit larger studies testing the hypothesis that postponing RFCA 1 month after VOM\u2010EI may increase its effectiveness in terms of fewer recurrences of atrial fibrillation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70072","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T17:40:15Z","timestamp":1760722815000},"page":"1244-1252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vein of Marshall Ethanol Infusion Related Lesion Durability: Looking for the Real Scar. Center\u2010Cluster, Case\u2010Control Study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2677-9214","authenticated-orcid":false,"given":"Procolo","family":"Marchese","sequence":"first","affiliation":[{"name":"Electrophysiology Unit Cardiology Department AST  Ascoli Piceno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Gennaro","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit Cardiology Department AST  Ascoli Piceno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Mazzotta","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit Cardiology Department AST  Ascoli Piceno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierfrancesco","family":"Grossi","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit Cardiology Department AST  Ascoli Piceno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6604-1756","authenticated-orcid":false,"given":"Luigi","family":"Cocchiara","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Advanced Biomedical Sciences Federico II University of Naples  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Brescia","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Advanced Biomedical Sciences Federico II University of Naples  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Mirarchi","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit Cardiology Department AST  Ascoli Piceno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim Shehab","family":"Eddine","sequence":"additional","affiliation":[{"name":"Electrophysiology Unit Cardiology Department AST  Ascoli Piceno Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Zaurino","sequence":"additional","affiliation":[{"name":"Interventional Electrophysiology Division Fondazione Toscana \u201cGabriele Monasterio\u201d  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Nesti","sequence":"additional","affiliation":[{"name":"Interventional Electrophysiology Division Fondazione Toscana \u201cGabriele Monasterio\u201d  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Mirizzi","sequence":"additional","affiliation":[{"name":"Interventional Electrophysiology Division Fondazione Toscana \u201cGabriele Monasterio\u201d  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Garibaldi","sequence":"additional","affiliation":[{"name":"Interventional Electrophysiology Division Fondazione Toscana \u201cGabriele Monasterio\u201d  Pisa 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