{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T14:53:56Z","timestamp":1764687236244,"version":"3.46.0"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>To evaluate the impact of pulsed\u2010field ablation (PFA) and radiofrequency catheter ablation (RFCA) on cardiac autonomic nerve system (ANS) function after pulmonary vein isolation (PVI) by monitoring heart rate (HR) and heart rate variability (HRV) changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort clinical study, patients with paroxysmal atrial fibrillation (AF) were enrolled consecutively into PFA or RFCA groups. HRV was assessed using the standard deviation of NN intervals (SDNN) and the standard deviation of the average NN intervals over 5\u2010min periods (SDANN). HR, SDNN, and SDANN were measured before PVI and 3 months after PVI using 24\u2010hour Holter\u00a0monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Acute electrical isolation was achieved in 100% of pulmonary veins (PVs) in the 72 patients. Over the 3\u2010month follow\u2010up, 36 of 36 patients in the PFA group and 36 of 36 patients in the RFCA group remained free from atrial arrhythmia episodes &gt;\u00a030\u00a0s. In the PFA group, there were no significant changes in HR, SDNN, and SDANN before and after PVI (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a00.05). The increase in HR in the PFA group was significantly lower than in the RFCA group (3.19\u00a0\u00b1\u00a010.50\u00a0vs. 10.86\u00a0\u00b1\u00a09.30\u00a0bpm;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0008). The decrease in HRV indices SDNN and SDANN in the PFA group was also significantly less than in the RFCA group (\u221210.72\u00a0\u00b1\u00a033.89\u00a0vs. \u221228.33\u00a0\u00b1\u00a030.55\u00a0ms;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.012, \u22124.67\u00a0\u00b1\u00a032.55\u00a0vs. \u221222.03\u00a0\u00b1\u00a027.46\u00a0ms;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PFA results in less damage to cardiac ANS function and preserves more cardiac ANS function compared with RFCA during PVI for paroxysmal AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70083","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:47:57Z","timestamp":1762159677000},"page":"1460-1465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Effects of PFA Versus RFCA on Cardiac Autonomic Nerve System Function After PVI: A Prospective Cohort Study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0968-1972","authenticated-orcid":false,"given":"Jianhua","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010yang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajie","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5827-7876","authenticated-orcid":false,"given":"Jingfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuanglun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sun Yat\u2010Sen Memorial Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.02.543"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.22.2237"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9040094"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac191"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.122.011598"},{"issue":"9","key":"e_1_2_11_7_1","first-page":"1864","article-title":"Impact of Pulsed\u2010Field Ablation on Intrinsic Cardiac Autonomic Nervous System After Pulmonary Vein Isolation","volume":"9","author":"Tohoku S.","year":"2023","journal-title":"Journal of the American College of Cardiology: Clinical 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P.","year":"2024","journal-title":"Journal of the American College of Cardiology: Clinical Electrophysiology"},{"issue":"5","key":"e_1_2_11_16_1","first-page":"614","article-title":"Pulsed Field Ablation of Paroxysmal Atrial Fibrillation: 1\u2010Year Outcomes of IMPULSE, PEFCAT, and PEFCAT II","volume":"7","author":"Reddy V. 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