{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T03:19:43Z","timestamp":1782962383955,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170327 82370332"],"award-info":[{"award-number":["82170327 82370332"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cryoballoon ablation is a safe and efficient rhythm control strategy in patients suffering from atrial fibrillation (AF). Diagnosis\u2010to\u2010ablation time (DAT) has been defined as a predictor of ablation outcomes, but the impact of early ablation among non\u2010paroxysmal AF is unclear. The aim of this study was to examine the impact of early cryoballoon ablation on AF recurrence in a prospective single\u2010center cohort of non\u2010paroxysmal AF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with non\u2010paroxysmal AF admitted to the Second Hospital of Tianjin Medical University until July 2024 and underwent first\u2010time cryoballoon ablation were enrolled. The patients were divided into two groups to evaluate differences in AF recurrence risk associated with early\u2010ablation (\n                      <jats:italic>n<\/jats:italic>\n                      = 78), defined as within 6 months of first AF diagnosis, and delayed\u2010ablation (\n                      <jats:italic>n<\/jats:italic>\n                      = 70), defined as &gt; 6 months after first AF diagnosis. The follow up was until October 31, 2024. Cox regression models were used to identify predictors of recurrence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 148 subjects were included and followed up for a mean of 293 (119\u2013398) days. The cohort included 78 (52.70%) in the early\u2010ablation group and 70 (47.30%) in the delayed\u2010ablation group. The mean age was 65.82 \u00b1 9.75 years and 56 (37.84%) were female. Multivariate Cox regression analysis showed that early\u2010ablation [hazard ratio (HR) = 0.496, 95% confidence interval (95% CI): 0.248\u20130.991,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.047], low\u2010density lipoprotein\/high\u2010density lipoprotein ratio (HR = 0.589, 95% CI: 0.377\u20130.920,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.020), and early recurrence (HR = 2.750, 95% CI: 1.418\u20135.333,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003) were independent predictors of AF recurrence after cryoballoon ablation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early cryoablation reduced the risk of recurrence in patients with non\u2010paroxysmal AF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70084","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T13:21:09Z","timestamp":1763472069000},"page":"172-179","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Impact of Early Cryoballoon Ablation on Clinical Outcomes in Patients With Non\u2010Paroxysmal Atrial Fibrillation"],"prefix":"10.1111","volume":"49","author":[{"given":"Wenhua","family":"Song","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runze","family":"Gao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Shangguan","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzhao","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Tse","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"School of Nursing and Health Sciences Hong Kong Metropolitan University  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology the Second Hospital of Tianjin Medical University  Tianjin 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