{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:53:30Z","timestamp":1791608010068,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012416","name":"Inova Health System","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012416","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Changes in tricuspid regurgitation (TR), mitral regurgitation (MR), and left ventricular ejection fraction (LVEF) are frequently noted after right ventricular apical (RVA) pacemaker implantation but prior studies evaluating whether left bundle branch area (LBBA), deep septal (DS), or leadless pacemaker implantation modify risk for those changes are limited. This study aims to compare changes in TR, MR, and LVEF after implantation of RVA, LBBA, DS, and leadless pacemakers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients were included if they underwent de novo pacemaker implantation for sinus node dysfunction or atrioventricular block and received pre\u2010 and post\u2010implant echocardiography. Change in TR, MR, and LVEF were analyzed using post\u2010hoc adjusted Kruskal\u2013Wallis and Chi\u2010squared testing, and multivariable ordinal logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 386 consecutive patients (RV,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0185; LBBA,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0122; DS,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a043, leadless,\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a036) the change in TR grade differed between pacemaker types (median [interquartile range] grade change: RVA 0[0,1], leadless 0[0,1], DS 0[0,1], LBBA 0[0,0];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01). In multivariable ordinal logistic regression, leadless (OR 2.41,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.01) and DS pacemakers (OR 2.44,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) predicted TR worsening compared to LBBA. The change in MR grade also differed between pacemaker types (grade change: RVA 0[0,1], leadless 0[0,1], DS 0[0,0], LBBA 0[\u22121,0];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03). The change in LVEF differed between pacemaker types (LVEF change: RVA \u22123[\u22129,3]%, leadless \u22125[\u221214,1]%, DS \u22123[\u221211,0]%, LBBA \u22121[\u22125,5]%;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The change in TR and MR grade and LVEF following pacemaker implant varied by pacemaker type. Compared to implantation with RVA, leadless, and DS pacemakers, LBBA pacemaker implantation was associated with more favorable changes in valvular and ventricular function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70087","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T13:23:17Z","timestamp":1763472197000},"page":"1344-1355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Valvular and Ventricular Function After Right Ventricular, Leadless, Deep Septal, and Left Bundle Branch Area Pacemakers"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1872-2611","authenticated-orcid":false,"given":"Anja","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Karolinska University Hospital, and Karolinska Institute  Stockholm Sweden"},{"name":"Inova Schar Heart and Vascular  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Karolinska University Hospital, and Karolinska Institute  Stockholm Sweden"},{"name":"Inova Schar Heart and Vascular  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutaz","family":"Alkalbani","sequence":"additional","affiliation":[{"name":"Inova Schar Heart and Vascular  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Emaminia","sequence":"additional","affiliation":[{"name":"Inova Schar Heart and Vascular  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunice","family":"Yang","sequence":"additional","affiliation":[{"name":"Inova Schar Heart and Vascular  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Ugander","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Karolinska University Hospital, and Karolinska Institute  Stockholm Sweden"},{"name":"Kolling Institute, Royal North Shore Hospital, and University of Sydney, St Leonard's  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett D.","family":"Atwater","sequence":"additional","affiliation":[{"name":"Inova Schar Heart and Vascular  Falls Church Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.017"},{"issue":"4","key":"e_1_2_11_3_1","first-page":"622","article-title":"Cardiac Implantable Electronic Device Lead\u2010Induced Tricuspid Regurgitation","volume":"12","author":"Addetia K.","year":"2019","journal-title":"JACC"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.08.004"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae143"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad783"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2024.05.003"},{"issue":"7","key":"e_1_2_11_8_1","first-page":"879","article-title":"Enhancing Cardiac Pacing Strategies: A Review of Conduction System Pacing Compared With Right and Biventricular Pacing and Their Influence on Myocardial Function","volume":"25","author":"Mirmaksudov M.","year":"2024","journal-title":"European Heart Journal"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-051022-042616"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15565"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"1237","article-title":"EHRA Clinical Consensus Statement on Conduction System Pacing Implantation: Executive Summary. Endorsed by the Asia\u2010Pacific Heart Rhythm Society (APHRS)","volume":"25","author":"Burri H.","year":"2023","journal-title":"Canadian Heart Rhythm Society (CHRS) and Latin\u2010American Heart Rhythm Society (LAHRS)"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12872"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2024.01.005"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad043"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.01.007"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.09.041"},{"issue":"5","key":"e_1_2_11_17_1","article-title":"Impact of Leadless Pacemaker Therapy on Cardiac and Atrioventricular Valve Function Through 12 Months of Follow\u2010Up","volume":"12","author":"Beurskens N. E. G.","year":"2019","journal-title":"Circulation"},{"issue":"5","key":"e_1_2_11_18_1","article-title":"Close Proximity of Leadless Pacemaker to Tricuspid Annulus Predicts Worse Tricuspid Regurgitation Following Septal Implantation","volume":"14","author":"Hai J.\u2010J.","year":"2021","journal-title":"Circulation"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16046"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/anec.12986"},{"issue":"2","key":"e_1_2_11_21_1","article-title":"Long\u2010Term Safety and Feasibility of Left Bundle Branch Pacing in a Large Single\u2010Center Study","volume":"14","author":"Su L.","year":"2021","journal-title":"Circulation"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.10.027"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.03.005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2023.07.064"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2021.07.007"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2015.07.002"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000001092"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.09.027"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.05.017"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14870"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac445"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T14:51:14Z","timestamp":1764687074000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/pace.70087"],"URL":"https:\/\/doi.org\/10.1111\/pace.70087","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"2025-07-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}