{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:04:45Z","timestamp":1774681485330,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170381"],"award-info":[{"award-number":["82170381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although preliminary studies have elucidated the clinical relevance of left anterior fascicular block (LAFB) in the general population, its specific impact on disease progression, cardiac functional deterioration, and adverse outcomes in heart failure patients remains underexplored. This study evaluated the short\u2010term prognostic value of LAFB in hospitalized heart failure patients and its influence on cardiac functional improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective cohort study enrolled 291 hospitalized heart failure patients from Beijing Anzhen Hospital. Patients were categorized into LAFB (\n                      <jats:italic>n<\/jats:italic>\n                      = 78) and no\u2010LAFB (\n                      <jats:italic>n<\/jats:italic>\n                      = 213) groups based on electrocardiographic findings using the Minnesota Code classification. The primary composite endpoint was all\u2010cause mortality and heart failure readmission at 6 months. Secondary endpoints included changes in left ventricular ejection fraction (LVEF), left ventricular end\u2010diastolic diameter (LVEDD), left ventricular end\u2010diastolic volume (LVEDV), and N\u2010terminal pro\u2010B\u2010type natriuretic peptide (NT\u2010proBNP) levels. Kaplan\u2013Meier survival analysis and multivariate Cox regression were performed to assess prognostic associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients with LAFB were older (70.46 \u00b1 12.88\u00a0vs. 64.98 \u00b1 13.42 years,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.002) and had worse baseline cardiac function, with lower LVEF (30.86 \u00b1 11.10%\u00a0vs. 33.80 \u00b1 8.49%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.036) and higher NT\u2010proBNP levels (2397.31 \u00b1 634.24\u00a0vs. 2161.23 \u00b1 612.14 pg\/mL,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004). Kaplan\u2013Meier analysis showed worse event\u2010free survival in the LAFB group (log\u2010rank\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012). Multivariate Cox regression indicated that the absence of LAFB was associated with a reduced risk of the primary composite endpoint (hazard ratio [HR] 0.48, 95% confidence interval [95% CI]: 0.23\u20130.99,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.048). At 6 months, the no\u2010LAFB group exhibited greater LVEF improvement (between\u2010group difference 2.94%, 95% CI: 0.55\u20135.33) and more pronounced reverse remodeling.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>LAFB is an independent predictor of adverse outcomes in hospitalized heart failure patients and is associated with reduced cardiac functional recovery, highlighting its potential for risk stratification and individualized therapeutic strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70101","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T08:56:01Z","timestamp":1766998561000},"page":"347-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Left Anterior Fascicular Block as a Predictor of Outcomes and Reduced Cardiac Functional Improvement in Heart Failure"],"prefix":"10.1111","volume":"49","author":[{"given":"JingXuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-1802","authenticated-orcid":false,"given":"Song","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing  Beijing 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Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JianZeng","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing  Beijing 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