{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:38:57Z","timestamp":1777628337484,"version":"3.51.4"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:00:00Z","timestamp":1769385600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Permanent pacing in pediatric patients is complicated by small body size, vascular access limitations, and the need for durable long\u2010term management. Leadless pacemakers offer an emerging alternative that minimizes infection and lead\u2010related complications, yet vascular access remains a key challenge in young patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report a 14\u2010year\u2010old male with congenital central hypoventilation syndrome (CCHS; PHOX2B polyalanine repeat mutation 20\/26) who presented with recurrent nocturnal oxygen desaturation secondary to prolonged sinus pauses despite tracheostomy\u2010assisted mechanical ventilation. Continuous implantable loop recorder monitoring confirmed pauses of up to 10 s, temporally associated with desaturation events. Given the small caliber of the femoral veins and the need for long\u2010term pacing, a leadless pacemaker was implanted via the right internal jugular vein. Device positioning was optimized under fluoroscopic guidance to achieve stable septal fixation with excellent electrical parameters (sensing: 9\u00a0mV; threshold 0.5\u00a0V at 0.24\u00a0ms; impedance: 530 \u03a9). The procedure and recovery were uneventful.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Follow\u2010up<\/jats:title>\n                    <jats:p>At 1\u2010year follow\u2010up, pacing burden was 1% with stable sensing and threshold parameters, and no recurrent desaturation episodes were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the complex interplay between arrhythmia and oxygen desaturation in CCHS, illustrating how permanent pacing can restore both rhythm and ventilatory stability. Transjugular leadless pacemaker implantation represents a safe and effective option for adolescents when femoral access is limited. In younger patients, careful anatomical assessment, awareness of long\u2010term device management, and individualized selection between retrievable and established systems are essential to optimize outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70146","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:43:39Z","timestamp":1769424219000},"page":"606-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transjugular Leadless Pacemaker Implantation in an Adolescent With Central Hypoventilation Syndrome: A Case Report"],"prefix":"10.1111","volume":"49","author":[{"given":"Marzia","family":"Giaccardi","sequence":"first","affiliation":[{"name":"Cardiology Department Santa Maria Annunziata Hospital  Florence Italy"},{"name":"Meyer Children's Hospital, IRCCS  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulio","family":"Porcedda","sequence":"additional","affiliation":[{"name":"Meyer Children's Hospital, IRCCS  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaccaria","family":"Ricci","sequence":"additional","affiliation":[{"name":"Meyer Children's Hospital, IRCCS  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Bonnemeier","sequence":"additional","affiliation":[{"name":"Christian\u2010Albrechts University Kiel  Kiel Germany"},{"name":"University of Applied Sciences  Bremerhaven Germany"},{"name":"Asklepios Hospital Schildautal Seesen  Seesen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benito","family":"Baldauf","sequence":"additional","affiliation":[{"name":"Christian\u2010Albrechts University Kiel  Kiel Germany"},{"name":"University of Applied Sciences  Bremerhaven Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz128"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-24-0083"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipej.2023.01.003"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13607"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010025\u201003402\u20103"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T01:39:30Z","timestamp":1777426770000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/pace.70146"],"URL":"https:\/\/doi.org\/10.1111\/pace.70146","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]},"assertion":[{"value":"2025-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}