{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:56:23Z","timestamp":1790697383425,"version":"4.1.0"},"reference-count":103,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Implantable cardioverter\u2010defibrillators (ICDs) are the cornerstone of sudden cardiac death prevention in cardiomyopathies, but disease\u2010specific structural and electrophysiological substrates profoundly affect device performance and outcomes. Understanding these distinctions is critical for tailoring therapy and improving patient safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Areas covered<\/jats:title>\n                    <jats:p>This review examines current evidence and practical experience regarding ICD implantation, programming, and management in hypertrophic cardiomyopathy (HCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), and cardiac amyloidosis (CA). We performed a structured narrative synthesis to identify phenotype\u2010specific technical challenges, programming strategies, and complication trends. For HCM, lead placement and programming to minimize inappropriate therapies are emphasized; for ARVC, issues of lead instability, oversensing, and ATP efficacy are explored; and for CA, defibrillation thresholds, sensing difficulties, and individualized indications are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Expert opinion<\/jats:title>\n                    <jats:p>ICD therapy in cardiomyopathies must be individualized, balancing arrhythmic protection against disease\u2010specific risks and device\u2010related complications. Tailored programming, careful system selection, and remote monitoring are key to improving outcomes. Emerging technologies such as modular and extravascular ICD systems promise safer and more phenotype\u2010driven care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70149","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:10:43Z","timestamp":1770120643000},"page":"449-465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When Substrate Meets Device: ICD Implantation and Therapy across the Spectrum of Cardiomyopathies"],"prefix":"10.1111","volume":"49","author":[{"given":"Nicol\u00f2","family":"Sisti","sequence":"first","affiliation":[{"name":"Division of Cardiology, Hospital of Gubbio\u2010Gualdo Tadino Regional Healthcare Unit  Gubbio Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cardona","sequence":"additional","affiliation":[{"name":"Advanced Cardiovascular Diagnostics Service Regional Healthcare Unit  Todi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovico","family":"Lazzari","sequence":"additional","affiliation":[{"name":"Clinical and Interventional Arrhythmology \u201cS. Maria\u201d Hospital  Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Fortuni","sequence":"additional","affiliation":[{"name":"Cardiology and Cardiovascular Pathophysiology, S. Maria della Misericordia Hospital University of Perugia  Perugia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amato","family":"Santoro","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Siena University Hospital  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Andreoli","sequence":"additional","affiliation":[{"name":"Department of Cardiology S.G. 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