{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:59:40Z","timestamp":1790697580900,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is associated with profound morbidity and mortality, including a fivefold increase in stroke risk. Left atrial appendage occlusion (LAAO) devices have emerged as an alternative approach to anticoagulation in patients with elevated bleeding risk and\/or have contraindications to anticoagulation. However, females have been underrepresented in PROTECT &amp; PREVAIL landmark trials supporting LAAO use. We aim to compare gender differences in outcomes of LAAO occlusive devices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The national readmission database (2016\u20132020) was utilized to identify hospitalizations for LAAO placement. Cohorts were stratified by gender as males and females. A propensity score matching (PSM) model matched both cohorts. Pearson's x2 test was applied to the matched cohorts to compare outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 89,552 hospitalizations for LAAO placement, 41.3% of procedures were performed in females. Females were found to have a lower prevalence of co\u2010morbidities such as diabetes, hypertension, hyperlipidemia and CKD [\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001].\n                    <\/jats:p>\n                    <jats:p>\n                      After propensity matching (\n                      <jats:italic>N<\/jats:italic>\n                      = 20,627), females had higher adverse events, including mortality (0.23%\u00a0vs. 0.15%,\n                      <jats:italic>p<\/jats:italic>\n                      : 0.041), sudden cardiac arrest (1.77%\u00a0vs. 1.37%,\n                      <jats:italic>p<\/jats:italic>\n                      : 0.001), pericardial complications (1.46%\u00a0vs. 0.86%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), cardiac tamponade (0.94%\u00a0vs. 0.54%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), post\u2010procedural bleeding (0.69%\u00a0vs. 0.53%,\n                      <jats:italic>p<\/jats:italic>\n                      : 0.032) &amp; net adverse events (4.73%\u00a0vs. 4.24%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). At six\u2010month follow\u2010up post\u2010procedure, females had higher readmission rates at 30 days (9.42%\u00a0vs. 8.07%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), 90\u2010day and 180\u2010day intervals (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with hospitalizations for LAAO device placement, we observed a higher risk of net adverse events and mortality in females following the procedure compared to males. Prospective trials are warranted to identify and stratify the at\u2010risk population with extensive preprocedural evaluation and determine ways to mitigate the sex\u2010related disparities in clinical outcomes following the LAAO procedure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70152","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:15:27Z","timestamp":1770120927000},"page":"403-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010Related Differences in Outcomes of Left Atrial Appendage Occlusion Device Placement"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-6041","authenticated-orcid":false,"given":"Shafaqat","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Louisiana State University Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5071-3971","authenticated-orcid":false,"given":"Sanchit","family":"Duhan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Carle Foundation Hospital\/Carle Illinois College of Medicine  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irisha","family":"Badu","sequence":"additional","affiliation":[{"name":"Department of Medicine Onslow Memorial Hospital  Jacksonville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine John H. Stroger, Jr. Hospital of Cook County  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thannon","family":"Alsaeed","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Louisiana State University Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faryal","family":"Farooq","sequence":"additional","affiliation":[{"name":"Department of Medicine Allama Iqbal Medical College Lahore  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijeta","family":"Keisham","sequence":"additional","affiliation":[{"name":"Department of Medicine Weifang Medical University  Weifang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2940-6074","authenticated-orcid":false,"given":"Abdul Rasheed","family":"Bahar","sequence":"additional","affiliation":[{"name":"Department of Medicine Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitsiri","family":"Atti","sequence":"additional","affiliation":[{"name":"Department of Medicine Sparrow Health  Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod Kumar","family":"Ponna","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Louisiana State University Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sewell","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Louisiana State University Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijaywant","family":"Brar","sequence":"additional","affiliation":[{"name":"Department of Medicine Sparrow Health  Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences Louisiana State University  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Helmy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences Louisiana State University  Shreveport Louisiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zain Ul Abideen","family":"Asad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, OU Health University of Oklahoma Medical Center  Oklahoma City Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paari","family":"Dominic","sequence":"additional","affiliation":[{"name":"Department of Cardiology Carver College of Medicine The University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.946"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100786"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017084"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00887-X"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.022274"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacadv.2022.100136"},{"key":"e_1_2_10_9_1","unstructured":"Boston Scientific Receives FDA Approval for WATCHMAN\u2122 Left Atrial Appendage Closure Device;First\u2010Of\u2010Its\u2010Kind Alternative to Long\u2010Term Warfarin Therapy for Stroke Risk Reduction in Patients With Non\u2010Valvular Atrial Fibrillation [press release].Boston Scientific Corporation;2015."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.114389"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.2029"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.53221"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h7013"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14838"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz151"},{"key":"e_1_2_10_17_1","unstructured":"HCUP Nationwide Readmissions Database (NRD).Healthcare Cost and Utilization Project (HCUP).2016\u20132020. 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