{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:39:19Z","timestamp":1777628359718,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T00:00:00Z","timestamp":1771286400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Termination of persistent atrial fibrillation (PersAF) during radiofrequency catheter ablation (RFCA) is closely related to the outcome of the ablation. Epicardial adipose tissue (EAT) plays an important role in the maintenance of AF. The role of EAT on the termination of PersAF has not been reported. The aim of this study was to evaluate the association between left atrial EAT (LA\u2010EAT) and termination of PersAF during pulmonary vein isolation (PVI).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This was a single\u2010center retrospective observational study. Consecutive enrolment of PersAF who underwent first\u2010time radiofrequency ablation between January 2021 and August 2022. All patients underwent computed tomography angiography (CTA) examination of the left atrium, and the LA\u2010EAT was measured using medical software (Advantage Workstation 4.6, GE, USA). Termination of PersAF during ablation was defined as conversion of AF to sinus rhythm (SR) or stable atrial flutter (AFL)\/atrial tachycardia (AT).<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 203 PersAF patients were enrolled, atrial fibrillation rhythm termination during PVI in 42 patients. Multivariate analysis showed that duration of AF, Heart failure (HF), and LA\u2010EAT volume (OR = 0.960; 95%CI: 0.926\u2013 0.996,\n p<\/jats:italic>\n = 0.029) were independent predictors of termination. ROC analysis showed that the model including AF duration, HF, and LA\u2010EAT had an effective ability to predict the termination (AUC = 0.734, 95% CI:0.647\u20100.802,\n p<\/jats:italic>\n \u00a0<\u00a00.001). When LA\u2010EAT was integrated into the model of characteristics routinely (including AF duration and HF), the discrimination and reclassification accuracy for the termination were significantly improved (NRI 0.2143, 95% CI 0.0724\u20100.3562,\n p<\/jats:italic>\n = 0.003; IDI 0.0291, 95% CI 0.0047\u20100.0535,\n p<\/jats:italic>\n = 0.019). The analysis revealed a statistically significant difference in overall arrhythmia recurrence between the termination group and non\u2010termination group (log\u2010rank\n p<\/jats:italic>\n = 0.038).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n LA\u2010EAT is independently associated with the termination of PersAF during PVI<\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Number<\/jats:title>\n Not applicable.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pace.70157","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T07:33:28Z","timestamp":1771400008000},"page":"531-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Atrial Epicardial Adipose Tissue Associated With Persistent AF Termination During Pulmonary Vein Isolation"],"prefix":"10.1111","volume":"49","author":[{"given":"Bowen","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Cardiology Qingdao Eighth People's Hospital Qingdao China"},{"name":"Department of Cardiology The Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Xuzhou Medical University Xuzhou China"},{"name":"Department of Cardiology Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanyi","family":"Sang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Northern Jiangsu People's Hospital Yangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Qingdao Eighth People's Hospital Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sihua","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Cardiology Qingdao Eighth People's Hospital Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Qingdao Eighth People's Hospital Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wensu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoqun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"issue":"11","key":"e_1_2_14_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.101330","article-title":"Prevalence, Management, and Comorbidities of Adults with Atrial Fibrillation in the United States, 2019 to 2023","volume":"3","author":"Oltman C. 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