{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:31:59Z","timestamp":1786386719428,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:00:00Z","timestamp":1771977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify sex\u2010based differences in meeting left bundle branch (LBB) capture criteria on postimplant ECGs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite differences in QRS duration (QRSd) between males and females, no sex\u2010based criteria have been established for defining LBB capture during LBB area pacing (LBBAP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients aged &gt;18 y.o. with a pacing indication and dual\u2010chamber LBBAP pacemaker implantation from 2020 to 2023 were studied. Baseline and postoperative day 1 (POD1) ECGs were assessed for electrical dyssynchrony (QRS\u2010area, sum\u2010absolute integral of QRS\u2010T (SAI QRS\u2010T)), with LBB capture defined based on R\u2010wave peak times (RWPT) per the EHRA 2023 Consensus algorithm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The cohort included 222 patients (143 males\/79 females, age 74.5\u00b11.1 years, LVEF 53.7\u00b10.4%). Baseline QRSd was significantly shorter among females than males (median 122\u00a0ms [90,134] vs 126\u00a0ms [102,146];\n                      <jats:italic>p<\/jats:italic>\n                      = 0.018). LBB capture criteria were met in 83 (58.0%) male and 56 (70.9%) female patients (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.058). Baseline and POD1 dyssynchrony were similar between sexes. However, RWPTs measured in leads V\n                      <jats:sub>6<\/jats:sub>\n                      \/I\/aVL were \u223c7\u00a0ms\n                      <jats:italic>shorter<\/jats:italic>\n                      in females than males (V\n                      <jats:sub>6<\/jats:sub>\n                      \u2010RWPT: 66.3 \u00b1 1.6\u00a0ms vs. 73.7 \u00b1 1.4\u00a0ms,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0008). Adjusting V\n                      <jats:sub>6<\/jats:sub>\n                      \u2010RWPT up by 7\u00a0ms in females resulted in 7\/56 patients (12.5%) no longer meeting LBB capture criteria. Significant differences were eliminated when normalizing RWPTs to size parameters (LV size, height, body surface area (BSA)), with no significant correlation between V\n                      <jats:sub>6<\/jats:sub>\n                      \u2010RWPT and size.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Females with LBB capture exhibit shorter V\n                      <jats:sub>6<\/jats:sub>\n                      \u2010RWPTs despite similar measures of electrical dyssynchrony. This difference disappears when normalizing for the smaller size of female hearts. Additional studies are warranted to establish sex\u2010specific LBB capture criteria.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70181","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:16:37Z","timestamp":1772957797000},"page":"1133-1142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex\u2010Based Differences in Left Bundle Branch Capture During Left Bundle Branch Area Pacing"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4501-0400","authenticated-orcid":false,"given":"Ilya Y.","family":"Shadrin","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Cardiology Duke University Hospital  Durham North Carolina USA"},{"name":"Duke Clinical Research Institute  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6984-815X","authenticated-orcid":false,"given":"Sara A.","family":"Coles","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Duke University Hospital  Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Graff","sequence":"additional","affiliation":[{"name":"Department of Health Science and Technology Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana M.","family":"Al\u2010Khatib","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Cardiology Duke University Hospital  Durham North Carolina USA"},{"name":"Duke Clinical Research Institute  Durham North Carolina 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