{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:08:57Z","timestamp":1784030937357,"version":"3.55.0"},"reference-count":11,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Conduction system pacing (CSP) is an emerging new method of cardiac resynchronization therapy (CRT), however, one third of patients with left bundle branch block (LBBB) have distal conduction disease, which is not amenable to correction with CSP. There is an emerging need for tailored analysis of ventricular depolarization patterns for patient selection for CRT pacing modality. We retrospectively analyzed 12 lead hrECGs, equivalent dipole (ED) trajectories and standard transthoracic echocardiograms of 18 heart failure patients fulfilling Strauss criteria for LBBB and indication for CRT randomized to the CSP arm of the ongoing CSP\u2010Sync study (NCT05155865). Based on achievement of left bundle branch capture with shortening of left ventricular activation time, 12 patients had proximal LBBB (pLBBB group), and 6 had intact proximal LBBB conduction (dLBBB group) with similar average baseline QRS durations between the groups (179\u00b114\u00a0ms in the pLBBB and 165\u00b120\u00a0ms in the dLBBB group,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.1). All patients fulfilled the Strauss criteria with no significant difference in the additional criterion (R wave &gt; 0.1\u00a0mV in V1;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.7). In the pLBBB group ED trajectory had an initial leftward direction (six\u00a0vs. zero patients,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.03) with a uniform (12\u00a0vs. one patient,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and slower (0.57 \u00b1 0.12 m\/s in the pLBBB vs. 0.75 \u00b1 0.15 m\/s in the dLBBB group,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.01) velocity. After 6 months the pLBBB group achieved greater relative QRS duration shortening (26% \u00b1 8% vs. 14% \u00b1 9%;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.02) and relative reductions in end left ventricle systolic volumes (41.3% \u00b1 17.6% vs. 15.8% \u00b1 6.1%;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.004) with better improvement in ejection fraction (17.1% \u00b1 11.0%\u00a0vs. 5.5% \u00b1 1.0%;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.02). The ED trajectories from 12\u2010lead hrECGs could better differentiate patients with proximal or distal LBBB than standard 12\u2010lead ECG alone.\n                  <\/jats:p>","DOI":"10.1111\/pace.70204","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:03:40Z","timestamp":1774119820000},"page":"1000-1004","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["In the Search of Noninvasive Methods Delineating Left Bundle Branch Block Amendable With Conduction System Pacing"],"prefix":"10.1111","volume":"49","author":[{"given":"Tadej","family":"\u017dlahti\u010d","sequence":"first","affiliation":[{"name":"University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito","family":"Starc","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"\u017di\u017eek","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Rauber","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bor","family":"Antoli\u010d","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miha","family":"Mrak","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Ivanovski","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja Zupan","family":"Me\u017enar","sequence":"additional","affiliation":[{"name":"University Medical Centre Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.062124"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2023.06.011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.05.009"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038648"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmccpl.2024.100061"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.06.016"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad043"},{"key":"e_1_2_11_10_1","doi-asserted-by":"crossref","unstructured":"V.Starc ed. \u201cLocalization of Ischemic Myocardial Segments From 12\u2010Lead ECG Using the Spatial ECG \u201d inProceedings of 2023 Computing in Cardiology (CinC)(IEEE 2023).","DOI":"10.22489\/CinC.2023.232"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eur381"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.5603\/KP.a2019.0032"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70204","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70204","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:47:49Z","timestamp":1784029669000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,21]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/pace.70204"],"URL":"https:\/\/doi.org\/10.1111\/pace.70204","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,21]]},"assertion":[{"value":"2024-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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