{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:32:01Z","timestamp":1786386721070,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Evaluate the comparative risk of hemolysis and acute kidney injury (AKI) with pulsed field ablation (PFA) versus thermal ablation (TA) for atrial fibrillation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Databases were searched through June 2025 for comparative studies reporting hemolysis markers or renal outcomes. Random\u2010effects models estimated risk ratios (RRs) and mean differences (MDs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight studies (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a04307) were included. Compared with TA, PFA was not associated with a statistically significant increase in AKI (RR 2.00, 95% CI 0.5\u20137.9) or change in creatinine (MD 0.02\u00a0mg\/dL,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.10). PFA was associated with higher LDH (MD +72\u00a0U\/L\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and lower haptoglobin (MD \u22120.60\u00a0g\/L\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PFA may be associated with greater biochemical hemolysis than TA; however, no statistically significant difference in AKI or post\u2010procedural creatinine was observed in pooled analyses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70225","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T12:38:31Z","timestamp":1774615111000},"page":"1221-1223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemolysis and Renal Outcomes After Pulsed Field Versus Thermal Ablation for Atrial Fibrillation: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2073-2986","authenticated-orcid":false,"given":"Cesar","family":"Erazo","sequence":"first","affiliation":[{"name":"Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Serpa","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Cavalcante Lima","family":"Chagas","sequence":"additional","affiliation":[{"name":"Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1310-1590","authenticated-orcid":false,"given":"Andre","family":"Rivera","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Arevalo","sequence":"additional","affiliation":[{"name":"Loma Linda University  Loma Linda California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Aguilera","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid America Heart Institute University of Missouri\u2010Kansas City  Kansas City Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-3499","authenticated-orcid":false,"given":"Kamala P.","family":"Tamirisa","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2024.04.012"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03114-3"},{"issue":"10","key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euae251","article-title":"Intravascular Haemolysis and Acute Kidney Injury following Atrial Fibrillation Ablation: A Report Using Two Different Systems for Pulsed Field Ablation","volume":"26","author":"De Smet M. A. J.","year":"2024","journal-title":"EP Europace: EHJ Arrhythmias and Electrophysiology"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2139\/ssrn.5029339"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.04.046"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.05.072"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2024.05.001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.124.012732"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.04.038"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2025.04.017"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(77)90252-8"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.08.026"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.07.026"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70225","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:27:17Z","timestamp":1786386437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,27]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/pace.70225"],"URL":"https:\/\/doi.org\/10.1111\/pace.70225","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,27]]},"assertion":[{"value":"2025-12-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}