{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T18:32:01Z","timestamp":1786386721660,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Implantable cardioverter\u2010defibrillators (ICDs) are essential for preventing sudden cardiac death in patients with ischemic cardiomyopathy (ICM). Noninvasive programmed stimulation (NIPS) is a potential tool for predicting ventricle tachycardia (VT) or ventricle fibrillation (VF) and helps to select patients with higher arrhythmic risk. This study aimed to evaluate the predictive value of NIPS in identifying ICM patients at risk for VT\/VF episodes and mortality after ICD implantation for primary prevention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, single\u2010center study included 50 patients with ICM who underwent ICD or CRT\u2010D implantation for primary prevention. NIPS was performed between 1\u2010 and 3\u2010months following implantation and patients were followed for VT\/VF recurrence and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Positive NIPS was observed in 20% of patients. During a median follow\u2010up of 5.67 years, VT\/VF occurred in 16% of patients. Kaplan\u2013Meier analysis demonstrated a significantly increased risk of VT\/VF episodes in the positive NIPS group (log\u2010rank test,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.047), with a considerably shorter time to VT\/VF incidence (0.58\u00a0vs. 4.75 years). NIPS was not positively associated with an increased mortality rate (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.45). However, elevated levels of creatinine and NT\u2010pro BNP were significantly associated with higher mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NIPS positivity predicts an increased risk of VT\/VF episodes, supporting its role in predicting arrhythmic episodes but not mortality after ICD implantation for primary prevention with ICM. Creatinine and NT\u2010proBNP levels were significantly associated with patient survival.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration<\/jats:bold>\n                      : This prospective study was not registered in a public clinical trials registry, as registration was not required at the time of study initiation\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70226","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:26:32Z","timestamp":1774675592000},"page":"1177-1184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Noninvasive Programmed Stimulation Predicts Arrhythmia in Ischemic Cardiomyopathy With ICDs for Primary Prevention"],"prefix":"10.1111","volume":"49","author":[{"given":"Grzegorz","family":"Karkowski","sequence":"first","affiliation":[{"name":"Department of Electrocardiology The St. John Paul II Hospital  Krak\u00f3w Poland"},{"name":"Department of Electrocardiolody Institute of Cardiology Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rydlewska","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology The St. John Paul II Hospital  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Z\u0105bek","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology The St. John Paul II Hospital  Krak\u00f3w Poland"},{"name":"Department of Electrocardiolody Institute of Cardiology Jagiellonian University Medical College  Krak\u00f3w Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mateusz","family":"Ulman","sequence":"additional","affiliation":[{"name":"Department of Electrocardiology The St. John Paul II Hospital  Krak\u00f3w 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