{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:45:38Z","timestamp":1792158338404,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T00:00:00Z","timestamp":1774828800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Leadless pacemakers (LPMs) have been shown to reduce complications compared with conventional transvenous pacing. Transfemoral venous access (FA) is the standard implantation approach; however, the transjugular approach (JA) has recently emerged as an alternative strategy, but comparative evidence remains limited. Therefore, we perform a systematic review and meta\u2010analysis comparing JA and FA for LPMs implantation in terms of electrical performance, procedural efficiency, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All studies comparing JA and FA for LPMs were systematically identified. Pooled analyses were performed for pacing threshold, sensed R\u2010wave amplitude, impedance, total procedural time, fluoroscopy duration, and procedural complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three observational studies were included. No significant differences were observed between FA and JA in mean pacing threshold (MD 0.05\u00a0ms; 95% CI \u22120.03 to 0.12), mean sensed R\u2010wave amplitude (MD 0.31\u00a0mV; 95% CI \u22120.51 to 1.14), or impedance (MD 45.79 \u03a9; 95% CI \u221227.03 to 118.61). Total procedural time was comparable between approaches (MD \u22120.44\u00a0min; 95% CI \u22128.47 to 7.60). JA was associated with a significant reduction in fluoroscopy time compared with FA (MD 2.73\u00a0min; 95% CI 0.66 to 4.81). JA also significantly reduced overall procedural complications (1.8%\u00a0vs. 15%; OR 0.12, 95% CI 0.04 to 0.39) and wound care\u2013related adverse events (0%\u00a0vs. 14%; OR 0.07, 95% CI 0.01 to 0.36). No differences were observed in device dislodgement, pericardial effusion, or emergent device removal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>JA provides comparable electrical performance to FA while reducing fluoroscopy exposure and access\u2010related complications, supporting its use as a safe alternative for LPMs implantation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70236","type":"journal-article","created":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:29:19Z","timestamp":1774859359000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Jugular Versus Femoral Venous Access for Leadless Pacemaker Implantation: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1392-2472","authenticated-orcid":false,"given":"Federico","family":"Giannino","sequence":"first","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Vetta","sequence":"additional","affiliation":[{"name":"Heart Rhythm Management Centre Postgraduate Program in Cardiac Electrophysiology and Pacing Universitair Ziekenhuis Brussel\u2010Vrije Universiteit Brussel European Reference Networks Guard\u2010Heart  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Card\u00ec","sequence":"additional","affiliation":[{"name":"Cardiology Unit, ASP5 Messina \u201cSan Vincenzo\u201d Hospital  Taormina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2779-0818","authenticated-orcid":false,"given":"Rodolfo","family":"Caminiti","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Crea","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Dattilo","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Sbriglione","sequence":"additional","affiliation":[{"name":"Cardiology Unit Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Cardiology Unit, ASP5 Messina \u201cSan Vincenzo\u201d Hospital  Taormina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Coluccia","sequence":"additional","affiliation":[{"name":"Cardiology Unit \u201cCard. G. Panico\u201d Hospital  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Cardiology Unit \u201cCard. G. Panico\u201d Hospital  Tricase Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosario","family":"Foti","sequence":"additional","affiliation":[{"name":"Cardiology Unit, ASP5 Messina \u201cSan Vincenzo\u201d Hospital  Taormina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Parlavecchio","sequence":"additional","affiliation":[{"name":"Cardiology Unit, ASP5 Messina \u201cSan Vincenzo\u201d Hospital  Taormina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,30]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac112"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17434440.2021.1921573"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2025.03.1881"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.07.040"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13607"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14587"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.70147"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae199"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-025-02159-9"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10840-025-02135-3"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_12_13_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5 (updated August 2024)","author":"Higgins J. P. 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