{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:19:19Z","timestamp":1786630759670,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T00:00:00Z","timestamp":1775952000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Biventricular pacing (BVP) and conduction system pacing (CSP) can enhance pacing\u2010induced cardiomyopathy (PICM) patients' clinical outcomes. Although BVP is a class I recommendation in guidelines, CSP may provide a superior physiological alternative to BVP. This meta\u2010analysis compares the efficacy and safety of CSP and BVP in PICM patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Databases including PubMed, Cochrane Library, Web of Science, and Embase were searched from their establishment to June 2025. Data analysis was performed using Stata 17.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty observational studies involving 821 patients with PICM were included, among which 360 patients were treated with BVP and 461 patients with CSP. Results showed CSP had a greater QRS duration (QRSd) reduction than BVP (MD\u00a0=\u00a0\u221253.26\u00a0ms, 95% CI: \u221258.13, \u221248.39\u00a0vs. MD\u00a0=\u00a0\u221230.69\u00a0ms, 95% CI: \u221235.79, \u221225.59) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001). After 15.6 months' follow\u2010up, CSP had a higher response rate (84.7%\u00a0vs.\u00a067.6%) (RR\u00a0=\u00a01.25, 95% CI: 1.14, 1.38) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and lower incidences of adverse outcomes and device\u2010related complications (14.0%\u00a0vs.\u00a020.1%) (RR\u00a0=\u00a00.7, 95% CI: 0.5, 0.98) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) than BVP. Subgroup analysis showed His bundle pacing (HBP) was associated with greater QRSd shortening, while left bundle branch area pacing (LBBAP) had lower thresholds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results indicate that upgrading to CSP in PICM patients significantly improves electrical synchrony, and correlates with higher response rates and lower adverse outcomes, suggesting CSP as a promising alternative pacing strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70243","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:49:49Z","timestamp":1776059389000},"page":"851-866","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Conduction System Versus Biventricular Pacing in Pacing\u2010Induced Cardiomyopathy: Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2226-4636","authenticated-orcid":false,"given":"Qing","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingbiao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound Jining Medical University  Jining China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3607-731X","authenticated-orcid":false,"given":"Haiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Shandong First Medical University &amp; Shandong Provincial Qianfoshan Hospital  Jinan 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