{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:14:53Z","timestamp":1788498893173,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Clinical data about pulsed field ablation (PFA) under deep sedation among patients with obstructive sleep apnea (OSA) are limited, while the optimal periprocedural monitoring is not established. We report our experience in PFA among patients with atrial fibrillation (AF) and OSA, using a continuous non\u2010invasive respiratory and hemodynamic monitoring protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 32 patients with AF suffering from OSA (mean age 68.5 \u00b19 years, 31% female) were compared with 60 consecutive patients without OSA. The monitoring protocol comprised continuous beat\u2010to\u2010beat blood pressure recording via an infrared light system and near\u2010infrared spectroscopy for both cerebral and peripheral tissue oximetry. The Acumen Hypotension Prediction Index (HPI) that detects hypotensive trending was also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three of the patients with OSA (9%) and four of the controls (6%) developed transient decrease of cerebral saturation during induction to deep sedation, early detected and effectively managed with airway manoeuvres and supplemental oxygen up\u2010titration. In nine patients with OSA (28%) and twenty controls (33%), increased HPI values followed by transient decrease in blood pressure were detected after induction to sedation and\/or during PFA, responsive to intravenous fluids. The average time of hypotension was comparable between patients with and without OSA (2.69% vs. 3.23% of the total procedure time, respectively). No serious complications occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PFA under deep sedation in patients with OSA and AF was not associated with higher incidence of adverse events compared to those without OSA. This is confirmed by a sensitive continuous non\u2010invasive monitoring protocol, which could be further evaluated by dedicated multicenter studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70260","type":"journal-article","created":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T06:14:35Z","timestamp":1776579275000},"page":"1395-1402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["PFA Under Deep Sedation and Non\u2010Invasive Monitoring in Atrial Fibrillation Patients With Obstructive Sleep Apnea"],"prefix":"10.1111","volume":"49","author":[{"given":"Dionyssios","family":"Leftheriotis","sequence":"first","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos A.","family":"Papathanasiou","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstratios","family":"Karamanolis","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areti","family":"Vlachodiamanti","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Stamatopoulou","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Polikandrioti","sequence":"additional","affiliation":[{"name":"Department of Nursing University of West Attica  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Flevari","sequence":"additional","affiliation":[{"name":"2nd Department of Cardiology Attikon University Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"issue":"4","key":"e_1_2_12_2_1","first-page":"25","article-title":"Novel Ablation Catheters for Atrial Fibrillation","volume":"25","author":"Kawamura I.","year":"2024","journal-title":"Reviews in Cardiovascular Medicine"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2024.02.009"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2022.45"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2021.02.014"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2021.09.026"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2019.100447"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.02.014"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.10.080"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcha.2021.100771"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.07.627"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304293281704"},{"key":"e_1_2_12_13_1","article-title":"Impact of Undiagnosed Obstructive Sleep Apnea on Atrial Fibrillation Recurrence Following Catheter Ablation (OSA\u2010AF study)","volume":"40","author":"de H. 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