{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:14:43Z","timestamp":1788498883287,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) frequently coexists with pulmonary hypertension (PH) and is associated with clinical deterioration, right ventricular dysfunction, and increased mortality. While catheter ablation has demonstrated superiority over anti\u2010arrhythmic drug (AAD) therapy in select AF populations, outcomes in patients with concurrent PH remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective cohort study using the TriNetX Research Network. Adults with AF and PH were identified and stratified by treatment with catheter ablation plus AAD or AAD therapy alone. After 1:1 propensity score matching for demographics, comorbidities, and medication use, 9759 patients were included in each cohort. The primary outcomes were major adverse cardiovascular events (MACE) and right heart failure. Secondary outcomes included all\u2010cause mortality, acute myocardial infarction (MI), and stroke. Kaplan\u2013Meier models were used as the primary analysis, with Cox proportional hazards and\n                      <jats:italic>E<\/jats:italic>\n                      \u2010value analysis as sensitivity. Competing risk analyses were performed using Fine\u2010Gray models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ablation was associated with a 50% reduction in MACE (HR 0.497 [0.467, 0.528],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and 35% reduction in right heart failure (HR 0.647 [0.573, 0.732],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). There were also significant reductions in all\u2010cause mortality (HR 0.469 [0.454, 0.488],\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and stroke (HR 0.819 [0.728, 0.922],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). There was no difference in acute MI (HR 0.982 [0.891, 1.082],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.710). Findings were consistent across Cox sensitivity analyses,\n                      <jats:italic>E<\/jats:italic>\n                      \u2010value analysis, and competing\u2010risk models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In AF patients with PH, catheter ablation with AAD therapy was associated with substantially lower risks of adverse cardiovascular outcomes compared with AAD therapy alone. These findings suggest that catheter ablation is associated with lower risks of adverse cardiovascular outcomes in this high\u2010risk population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70266","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T14:51:12Z","timestamp":1776783072000},"page":"1403-1411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Catheter Ablation in Atrial Fibrillation Patients With Pulmonary Hypertension"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2095-8134","authenticated-orcid":false,"given":"Md","family":"Fahim","sequence":"first","affiliation":[{"name":"Division of Internal Medicine SUNY Downstate Health Sciences University  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoud","family":"Eldawud","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine SUNY Downstate Health Sciences University  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Osei","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine SUNY Downstate Health Sciences University  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Godslove","family":"Bonnah","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine SUNY Downstate Health Sciences University  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine SUNY Downstate Health Sciences University  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Khouri","sequence":"additional","affiliation":[{"name":"College of Medicine SUNY Downstate Health Sciences University  Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0179-3930","authenticated-orcid":false,"given":"Adam S.","family":"Budzikowski","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine\u2014Electrophysiology Section SUNY Downstate Health Sciences University  Brooklyn New York 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