{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T05:14:39Z","timestamp":1788498879697,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Postoperative arrhythmias are common after coronary artery bypass graft (CABG) surgery and are linked to adverse outcomes. Colchicine, an anti\u2010inflammatory agent, has shown inconsistent results in prior studies, possibly due to dosing and timing variations.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n To evaluate the efficacy and safety of short\u2010term, weight\u2010adjusted colchicine initiated preoperatively for preventing postoperative arrhythmias after CABG.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this randomized, double\u2010blind, placebo\u2010controlled trial, 172 adults scheduled for on\u2010pump CABG received colchicine or placebo. The regimen included a preoperative loading dose (1\u00a0mg twice daily) followed by a weight\u2010based maintenance dose (0.5\u00a0mg daily if <70\u00a0kg; 1\u00a0mg daily if \u226570\u00a0kg) for 14 days. The primary outcome was incidence of postoperative atrial fibrillation (POAF). Secondary outcomes included early (\u226448\u00a0h) and late (>48\u00a0h) POAF, other arrhythmias, inflammatory markers (CRP, ESR), length of stay, and adverse events.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 163 analyzed patients (81 colchicine, 82 placebo), POAF incidence was significantly lower in the colchicine group (17.3%\u00a0vs. 46.3%; RR 0.37, 95% CI 0.21\u20130.66;\n p<\/jats:italic>\n < 0.001), with an absolute risk reduction of 29.0% and number needed to treat (NNT) of 4. Colchicine reduced both early and late POAF (\n p<\/jats:italic>\n < 0.001 and\n p<\/jats:italic>\n = 0.002). No significant reduction was seen in other arrhythmias. Gastrointestinal events, primarily diarrhea, were more common with colchicine (25.9%\u00a0vs. 8.5%,\n p<\/jats:italic>\n = 0.003), but were manageable and without serious adverse events.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Short\u2010term perioperative weight\u2010adjusted colchicine is effective and safe for preventing POAF after CABG, with a low NNT and manageable side effects, though it did not significantly affect other arrhythmias.<\/jats:p>\n <\/jats:sec>\n \n Trial Registration<\/jats:title>\n Iranian Registry of Clinical Trials, IRCT20200328046886N6<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/pace.70278","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:06:34Z","timestamp":1778756794000},"page":"1425-1433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Short\u2010Term, Weight\u2010Adjusted Colchicine to Prevent Post\u2010CABG Arrhythmias: A Randomized, Double\u2010Blind, Controlled Trial"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0854-8965","authenticated-orcid":false,"given":"Amir Hassan","family":"Farzaneh","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamideh","family":"Abbaspour","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valiollah","family":"Habibi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Fatemeh Zahra Hospital Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Javad","family":"Sadraei","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Fatemeh Zahra Hospital Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masood","family":"Darayi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Fatemeh Zahra Hospital Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siavash","family":"Moradi","sequence":"additional","affiliation":[{"name":"Education Development Center Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfazl Hossein","family":"Nataj","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Faculty of Health Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000659"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2020.05.104"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13507"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-019-00365-1"},{"issue":"2","key":"e_1_2_14_6_1","first-page":"206","article-title":"Update on Management of Postoperative Atrial Fibrillation After Cardiac Surgery","volume":"35","author":"RdM R.","year":"2020","journal-title":"Brazilian Journal of Cardiovascular Surgery"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14030882"},{"issue":"1","key":"e_1_2_14_8_1","article-title":"Interventions for Preventing Post\u2010Operative Atrial Fibrillation in Patients Undergoing Heart Surgery","volume":"2013","author":"Arsenault K. 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S.","year":"2016","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq319"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0000000000000889"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.04.022"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70278","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70278","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:23:21Z","timestamp":1788495801000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,14]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1111\/pace.70278"],"URL":"https:\/\/doi.org\/10.1111\/pace.70278","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,14]]},"assertion":[{"value":"2026-02-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}