{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:51:12Z","timestamp":1791258672376,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Implantable cardioverter\u2010defibrillator (ICD) therapy relies on reliable right ventricular leads for pacing, sensing, and defibrillation. The INVICTA DF4 lead is an active\u2010fixation, quadripolar design intended to optimize implant workflow and long\u2010term safety and performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>APOLLO was a prospective, multicenter, single\u2010arm, observational study enrolling adults across Europe with guideline\u2010based indications for de novo ICD or Cardiac Resynchronization Therapy Defibrillator (CRT\u2010D) implantation who received an INVICTA DF4 lead (single\u2010 or dual\u2010coil; 58 or 68\u00a0cm). The co\u2010primary endpoints focused on safety and performance at 3 months, while secondary endpoints included long\u2010term electrical variables, arrhythmia termination, and lead\u2010related complications through 24 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between June 4, 2021, and October 19, 2022, 446 patients were implanted across 45 sites in 8 European countries. The INVICTA lead was successfully implanted in 100% of the 446 enrolled patients. Leads were positioned either in the apex in 57.2% or right ventricle (RV) septum in 42.8%. Electrical variables stabilized after discharge and remained stable up to 24 months (M24 mean pacing threshold 0.85 \u00b1 0.33\u00a0V at 0.5\u00a0ms; sensing 13.39 \u00b1 3.17\u00a0mV; pacing impedance 525.5 \u00b1 94.2 Ohms; right ventricular (RV) coil continuity 427.8 \u00b1 82.7 Ohms). Of 86 arrhythmic episodes requiring defibrillation, 97.7% were successfully terminated. Lead\u2010related complication free rate was 97.5% at 30 days, 98.9% at 31\u2013730 days, and 96.4% overall. Mortality was 8.5% (38\/446) at two years, of which 63% was due to cardiovascular causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a large, contemporary European cohort, the INVICTA DF4 ventricular lead demonstrated high implant success, durable electrical performance, effective arrhythmia termination, and low complication rates through 24 months. A trend toward less complication in septal positioning was observed compared to apical placement, with comparable electrical performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70286","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:08:15Z","timestamp":1778944095000},"page":"1595-1603","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and Performance of INVICTA DF4 Ventricular Defibrillation Lead: Results From APOLLO Prospective Multicenter Study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7146-7105","authenticated-orcid":false,"given":"Klaus K.","family":"Witte","sequence":"first","affiliation":[{"name":"Medizinische Klinik I Kardiologie Pneumologie Angiologie Und Internistische Intensivmedizin Universitatsklinikum Aachen  Aachen North Rhine\u2010Westphalia Germany"},{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine Faculty of Medicine and Health University of Leeds  Leeds West Yorkshire UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2255-3530","authenticated-orcid":false,"given":"Juan Gabriel","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Arrhythmia Unit Hospital General Universitario Dr Balmis Servicio de Cardiologia  Alicante, Valencian Community Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio M.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Cardiology Department, Arrhythmia Unit Unidade Local de Saude Sao Jose  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Barrera","sequence":"additional","affiliation":[{"name":"Cardiology Department, Arrhythmia Unit Hospital Universitario Virgen De La Victoria  M\u00e1laga Andalusia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Izquierdo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Arrhythmia Unit Hospital Universitari i Politecnic La Fe  Valencia, Valencian Community Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cosimo","family":"Mandurino","sequence":"additional","affiliation":[{"name":"Cardiology Unit Ospedale SS Annunziata Taranto  Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Emilce","family":"Trucco","sequence":"additional","affiliation":[{"name":"Cardiology Department, Arrhythmia Unit Hospital Universitari de Girona Doctor Josep Trueta  Girona Catalonia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Juan","family":"Garc\u00eda Salvador","sequence":"additional","affiliation":[{"name":"Cardiology Department, Arrhythmia Unit Hospital Universitario de Gran Canaria Dr Negrin  Las Palmas de Gran Canaria, Canary islands Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Dompnier","sequence":"additional","affiliation":[{"name":"Service De Cardiologie Centre Hospitalier Annecy Genevois  Epagny Metz\u2010Tessy, Auvergne\u2010Rh\u00f4ne\u2010Alpes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Jean","sequence":"additional","affiliation":[{"name":"Service De Cardiologie m\u00e9dicale et M\u00e9decine Vasculaire Centre Hospitalier Universitaire Clermont\u2010Ferrand  Clermont\u2010Ferrand, Auvergne\u2010Rh\u00f4ne\u2010Alpes France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6863-2715","authenticated-orcid":false,"given":"Pablo J. S\u00e1nchez","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Cardiology Department, Arrhythmia Unit Hospital Universitario Virgen De Las Nieves Servicio De Cardiologia  Granada Andalusia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Israel","sequence":"additional","affiliation":[{"name":"Klinik F\u00fcr Innere Medizin \u2013 Kardiologie, Diabetologie und Nephrologie Evangelisches Klinikum Bethel GgmbH  Bieflefeld North Rhine\u2010Westphalia Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Martino","sequence":"additional","affiliation":[{"name":"MicroPort CRM  Saluggia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Marques","sequence":"additional","affiliation":[{"name":"Cardiology Department, Arrhythmia Unit Unidade Local de Saude Santa Maria  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus034"},{"issue":"11","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1093\/europace\/euv319","article-title":"2015 ESC Guidelines for the Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: The Task Force for the Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC)Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC)","volume":"17","author":"Priori S. 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S.","year":"2017","journal-title":"Brazilian Journal of Cardiovascular Surgery"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2021.12.007"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu304"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcdd9120444"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:11:44Z","timestamp":1791256304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":13,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/pace.70286"],"URL":"https:\/\/doi.org\/10.1111\/pace.70286","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,16]]},"assertion":[{"value":"2026-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}