{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:48:03Z","timestamp":1782575283687,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Left bundle branch block (LBBB) is a conduction abnormality that alters the pattern of left ventricular (LV) activation and contraction, leading to ventricular remodeling, typically manifesting as LV hypertrophy and dilatation. This remodeling is often associated with progressive cardiac dysfunction and a poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare temporal changes in left ventricular strain patterns in patients with typical and atypical LBBB over a period of two years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Electrocardiographic, echocardiographic, and strain parameters were obtained at two\u2010year follow\u2010up from previously enrolled patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 181 patients initially enrolled, 152 were contacted telephonically. Among them, 23 patients underwent follow\u2010up evaluation, 4 patients received cardiac resynchronization therapy (CRT), and 21 deaths were recorded. Significant changes between baseline and follow\u2010up were observed in left ventricular end\u2010diastolic dimension (LVEDD), left ventricular filling time (LVFT), LVFT\/R\u2010R interval, three\u2010dimensional systolic dyssynchrony index (SDI), and left ventricular ejection fraction (EF). Compared with survivors, non\u2010survivors had significantly lower baseline EF, and global longitudinal strain (GLS). An ALEF \u226440% was identified as a significant predictor of mortality. Multivariable regression analysis demonstrated that ALEF, GLS, and age were independent predictors of mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The all\u2010cause mortality rate over two years among patients with LBBB was 13.8%. Age, ALEF, and GLS were significant predictors of mortality. Improvements in left ventricular function and ventricular dyssynchrony were observed during follow\u2010up; however, the factors contributing to these changes could not be determined from the present study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>Clinical Trials Registry\u2014India on 02\/05\/2023 under the reference number CTRI\/2023\/05\/052206.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70334","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T15:20:32Z","timestamp":1782573632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Temporal Changes in Left Ventricular Strain in Typical and Atypical Left Bundle Branch Block Patients: A Follow\u2010up Study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3777-1531","authenticated-orcid":false,"given":"Abhishek K.","family":"Shetty","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Technology, Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9908-2891","authenticated-orcid":false,"given":"Mukund A.","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Kasturba Medical College, Manipal Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7376-0834","authenticated-orcid":false,"given":"Krishnananda","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Technology, Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-2857","authenticated-orcid":false,"given":"Jyothi","family":"Samanth","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Technology, Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1821-6306","authenticated-orcid":false,"given":"Hazel Lolita","family":"Mathias","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Technology, Manipal College of Health Professions Manipal Academy of Higher Education  Manipal Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"D.ScherbakandG. 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