{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:55:30Z","timestamp":1782496530910,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ventricular tachycardia (VT) ablation outcomes in nonischemic cardiomyopathy (NICM) may differ by disease phenotype, but prior studies have pooled NICM as a single entity. We performed a phenotype\u2010stratified meta\u2010analysis of VT ablation outcomes across six major NICM subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Embase, and the Cochrane Library through January 2026. Studies were stratified by phenotype: lamin A\/C (LMNA), cardiac sarcoidosis, dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), myocarditis, and arrhythmogenic right ventricular cardiomyopathy (ARVC). The primary outcome was VT recurrence. Proportions were pooled using restricted maximum likelihood estimation on the logit scale. Phenotype differences were tested via mixed\u2010effects meta\u2010regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighteen studies (1699 patients) met inclusion criteria after rigorous center\u2010level overlap resolution. VT recurrence differed significantly across phenotypes (F [5,12] = 3.78,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.027). LMNA had the highest recurrence (82.6%; 95% CI 51.6%\u201395.5%;\n                      <jats:italic>k<\/jats:italic>\n                      = 5), followed by sarcoidosis (57.1%; 32.2%\u201378.8%;\n                      <jats:italic>k<\/jats:italic>\n                      = 2), DCM (42.7%; 24.1%\u201363.6%;\n                      <jats:italic>k<\/jats:italic>\n                      = 4), HCM (36.2%; 23.8%\u201350.7%;\n                      <jats:italic>k<\/jats:italic>\n                      = 2), myocarditis (34.5%; 27.3%\u201342.5%;\n                      <jats:italic>k<\/jats:italic>\n                      = 2), and ARVC (33.8%; 16.0%\u201357.9%;\n                      <jats:italic>k<\/jats:italic>\n                      = 3). Phenotype explained 44.7% of between\u2010study heterogeneity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>VT ablation outcomes in NICM varied by the underlying disease phenotype, with recurrence rates ranging from 82.6% in LMNA cardiomyopathy to 33.8% in ARVC. These hypothesis\u2010generating findings argue against treating NICM as a unified category and provide a foundation for phenotype\u2010specific procedural counseling and clinical trial stratification that warrants validation in prospective registries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70340","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:41:28Z","timestamp":1782495688000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Phenotype on Recurrence of VT Post\u2010Ablation in Patients With Nonischemic Cardiomyopathy"],"prefix":"10.1111","author":[{"given":"Shreyas","family":"Singireddy","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine University of Illinois College of Medicine  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Shoura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Illinois College of Medicine  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshine","family":"Venugopal","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Illinois College of Medicine  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chinnatambi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Piedmont Athens Regional Medical Center  Athens Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddharth","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Illinois College of Medicine  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Sparrow","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Illinois College of Medicine  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timir","family":"Baman","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Illinois College of Medicine  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Mehrotra","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine University of Illinois College of Medicine  Peoria Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1016\/j.hrthm.2019.03.002","article-title":"2019 HRS\/EHRA\/APHRS\/LAHRS Expert Consensus Statement on Catheter Ablation of Ventricular Arrhythmias","volume":"17","author":"Cronin E. M.","year":"2020","journal-title":"Heart Rhythm"},{"issue":"9","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jacep.2018.05.007","article-title":"Outcomes of Catheter Ablation of Ventricular Tachycardia Based on Etiology in Nonischemic Heart Disease","volume":"4","author":"Vaseghi M.","year":"2018","journal-title":"JACC Clinical Electrophysiology"},{"issue":"10","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.hrthm.2016.07.001","article-title":"Long\u2010Term Outcomes After Catheter Ablation of Ventricular Tachycardia in Patients With and Without Structural Heart Disease","volume":"13","author":"Kumar S.","year":"2016","journal-title":"Heart Rhythm"},{"issue":"12","key":"e_1_2_8_5_1","article-title":"Outcomes of Catheter Ablation for Ventricular Tachycardia in Lamin A\/C Cardiomyopathy","volume":"13","author":"Sidhu B. S.","year":"2020","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"2","key":"e_1_2_8_6_1","article-title":"Outcomes of Catheter Ablation of Ventricular Tachycardia in Cardiac Sarcoidosis","volume":"15","author":"Siontis K. C.","year":"2022","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"87","article-title":"Ventricular Tachycardia in Cardiac Sarcoidosis","volume":"8","author":"Kumar S.","year":"2015","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"11","key":"e_1_2_8_8_1","first-page":"1886","article-title":"Clinical Outcomes of Catheter Ablation of Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy","volume":"18","author":"Daimee U. A.","year":"2021","journal-title":"Heart Rhythm"},{"issue":"9","key":"e_1_2_8_9_1","first-page":"686","article-title":"Early Referral for Ablation of Scar\u2010Related Ventricular Tachycardia is Associated With Improved Acute and Long\u2010Term Outcomes","volume":"101","author":"Dinov B.","year":"2015","journal-title":"Heart"},{"issue":"5","key":"e_1_2_8_10_1","first-page":"750","article-title":"Catheter Ablation of Ventricular Tachycardia in ARVC: A Chinese registry","volume":"17","author":"Liang J. J.","year":"2020","journal-title":"Heart Rhythm"},{"issue":"9","key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.jacc.2020.01.036","article-title":"Ventricular Arrhythmias in Myocarditis","volume":"75","author":"Peretto G.","year":"2020","journal-title":"Journal of the American College of Cardiology"},{"issue":"3","key":"e_1_2_8_12_1","first-page":"345","article-title":"Catheter Ablation of Ventricular Tachycardia in Myocarditis","volume":"21","author":"Li A.","year":"2024","journal-title":"Heart Rhythm"},{"issue":"6","key":"e_1_2_8_13_1","first-page":"1413","article-title":"Long\u2010Term Outcome With Catheter Ablation of VT in ARVC","volume":"8","author":"Santangeli P.","year":"2015","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"1","key":"e_1_2_8_14_1","first-page":"88","article-title":"Catheter Ablation of VT in LMNA Cardiomyopathy: A Systematic Review","volume":"36","author":"Castrichini M.","year":"2025","journal-title":"Journal of Cardiovascular Electrophysiology"},{"issue":"12","key":"e_1_2_8_15_1","first-page":"2093","article-title":"Catheter Ablation of VT in Cardiac Sarcoidosis: A Systematic Review","volume":"19","author":"Adhaduk M.","year":"2022","journal-title":"Heart Rhythm"},{"issue":"5","key":"e_1_2_8_16_1","first-page":"1178","article-title":"Catheter Ablation of VT in Hypertrophic Cardiomyopathy: A Systematic Review","volume":"34","author":"Garg L.","year":"2023","journal-title":"Journal of Cardiovascular Electrophysiology"},{"issue":"9","key":"e_1_2_8_17_1","first-page":"1512","article-title":"Catheter Ablation of VT in Dilated Cardiomyopathy: A Systematic Review","volume":"24","author":"Ammar S.","year":"2022","journal-title":"Europace"},{"issue":"4","key":"e_1_2_8_18_1","first-page":"654","article-title":"Catheter Ablation of Ventricular Arrhythmias in Lamin A\/C Cardiomyopathy","volume":"22","author":"Ebert M.","year":"2020","journal-title":"Europace"},{"issue":"12","key":"e_1_2_8_19_1","article-title":"Catheter Ablation for VT in LMNA Cardiomyopathy","volume":"13","author":"Sidhu B. S.","year":"2020","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"3","key":"e_1_2_8_20_1","article-title":"Ventricular Arrhythmias in Laminopathies: Catheter Ablation Outcomes","volume":"26","author":"Cabrera\u2010Borrego E.","year":"2024","journal-title":"Europace"},{"issue":"8","key":"e_1_2_8_21_1","first-page":"1756","article-title":"Ventricular Tachycardia Ablation in LMNA Cardiomyopathy","volume":"34","author":"Kovacs B.","year":"2023","journal-title":"Journal of Cardiovascular Electrophysiology"},{"issue":"12","key":"e_1_2_8_22_1","first-page":"3420","article-title":"Catheter Ablation of VT in Dilated Cardiomyopathy","volume":"11","author":"Chakarov I.","year":"2022","journal-title":"Journal of Clinical Medicine"},{"issue":"5","key":"e_1_2_8_23_1","first-page":"992","article-title":"Catheter Ablation of Ventricular Tachycardia in Nonischemic Heart Disease","volume":"5","author":"Tokuda M.","year":"2012","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"1","key":"e_1_2_8_24_1","first-page":"156","article-title":"Catheter Ablation for VT in Hypertrophic Cardiomyopathy","volume":"24","author":"Dong H.","year":"2024","journal-title":"BMC Cardiovascular Disorders [Electronic Resource]"},{"key":"e_1_2_8_25_1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/jce.70193","article-title":"Outcomes of Ventricular Tachycardia Ablation in Cardiac Laminopathy: An Updated Systematic Review and Single\u2010Arm Meta\u2010Analysis","volume":"37","author":"Castrichini M.","year":"2026","journal-title":"Journal of Cardiovascular Electrophysiology"},{"issue":"3","key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jacep.2023.10.023","article-title":"Mapping and Ablation of Ventricular Tachycardia in Inherited Left Ventricular Cardiomyopathies","volume":"10","author":"Zeppenfeld K.","year":"2024","journal-title":"JACC Clinical Electrophysiology"},{"issue":"8","key":"e_1_2_8_27_1","article-title":"Long\u2010Term Outcome After Ventricular Tachycardia Ablation in Nonischemic Cardiomyopathy: Late Potential Abolition and VT NonInducibility","volume":"13","author":"Okubo K.","year":"2020","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"3","key":"e_1_2_8_28_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jacep.2017.12.020","article-title":"Radiofrequency Catheter Ablation of Ventricular Tachycardia in Patients With Hypertrophic Cardiomyopathy and Apical Aneurysm","volume":"4","author":"Igarashi M.","year":"2018","journal-title":"JACC Clinical Electrophysiology"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70340","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70340","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70340","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T17:41:31Z","timestamp":1782495691000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":27,"alternative-id":["10.1111\/pace.70340"],"URL":"https:\/\/doi.org\/10.1111\/pace.70340","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"assertion":[{"value":"2026-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pace.70340"}}