{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:20:59Z","timestamp":1783081259578,"version":"3.54.6"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:00:00Z","timestamp":1783036800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The head\u2010up tilt test (HUTT) diagnoses Vasovagal Syncope (VVS) but its duration limits adoption. We evaluated a shortened HUTT protocol in patients from Central China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 614 patients (median age 53.5 years, 53.2% female) with suspected VVS. All underwent a standardized HUTT with a 10\u00a0min passive phase at 70\u00b0, followed, if negative, by a 15\u00a0min active phase with 0.5\u00a0mg sublingual nitroglycerin. The overall positivity rate was 60.91% (374\/614), with the vast majority (359\/374) of positive responses occurring during the active phase. The median positive response time was 10\u00a0min (IQR: 6.5\u201310) for the passive phase and 3\u00a0min (IQR: 2\u20135min) for the active phase, with peak incidences observed at these intervals. The positivity rates for the 10\u00a0min and 15\u00a0min active phases were 58.63% and 60.91%, respectively, with no statistically significant difference (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.449). Through generalized additive model (GAM) analysis with inflection point detection, a significant nonlinear relationship between time and positivity was identified (EDF = 2.302,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Independent predictors of a positive test included female gender, increasing age, prior syncope before HUTT, and lower systolic blood pressure at 10\u00a0min of the passive phase.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our shortened HUTT protocol achieved comparable diagnostic yield in these patients while reducing test duration. Compared with the consensus\u2010recommended protocol, the shortened HUTT protocol saved at least 37.5% of the total test time, while achieving a positive rate (60.91%).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70344","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T11:41:18Z","timestamp":1783078878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tilt Test Duration in Suspected Vasovagal Syncope: Temporal Patterns and Diagnostic Yield in Patients From Central China"],"prefix":"10.1111","author":[{"given":"Rui","family":"Wu","sequence":"first","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Department of Cardio\u2010Pulmonary Function Fuwai Central China Cardiovascular Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayan","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Function Fuwai Central China Cardiovascular Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Function Fuwai Central China Cardiovascular Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardio\u2010Pulmonary Function Fuwai Central China Cardiovascular Hospital  Zhengzhou Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Gao","sequence":"additional","affiliation":[{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular 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