{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:05:44Z","timestamp":1784041544402,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The prognostic relevance of implantable cardioverter defibrillator (ICD) in patients with end\u2010stage heart failure (HF) with left ventricular assist device (LVAD) remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the prognostic impact of ongoing use of ICD and associated complications in HF\u2010patients with LVAD\u2010implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed all consecutive patients (\n                      <jats:italic>n<\/jats:italic>\n                      = 351) who underwent LVAD\u2010implantation and follow up between 2009 and 2021. Patients were categorized according to the presence (\n                      <jats:italic>n<\/jats:italic>\n                      = 254) or absence (\n                      <jats:italic>n<\/jats:italic>\n                      = 97) of ICD. To reduce baseline imbalances between groups, propensity score matching (PSM) was performed, yielding two matched cohorts of 79 patients each. The primary endpoint was a composite of all\u2010cause mortality and heart transplantation. Secondary endpoints included all\u2010cause mortality, heart transplantation, and ICD\u2010related complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Median age was 58 [49\u201365] years, and 85% were male. Median follow\u2010up duration was 3.6 [2.6\u20135.7] years. The primary endpoint revealed significantly less events in the ICD cohort (44.3%\u00a0vs. 59.5% (HR 0.6 95%CI [0.40; 0.97],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.035)). The difference was driven by a higher rate of all\u2010cause mortality (22.08%\u00a0vs. 41.8%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008), while the heart transplantation rate was similar (17.7%\u00a0vs. 21.5%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.98). ICD\u2010related complications occurred in 20.4% of all ICD\u2010patients, including 27 lead revisions, 8 complete system removals due to infection, 13 inadequate shocks and 4 hematoma evacuations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ICD therapy was associated with lower mortality in this single\u2010center LVAD\u2010cohort. However, this finding contrasts with recent meta\u2010analytic. Given the substantial burden of ICD\u2010related complications, ICD\u2010management after LVAD\u2010implantation should be individualized according to arrhythmic risk, pacing requirements, procedural risk, and patient preferences.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70351","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:27:50Z","timestamp":1783754870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of ICD Presence in Patients With Left Ventricular Assist Devices for End\u2010Stage Heart Failure"],"prefix":"10.1111","author":[{"given":"Nafilah","family":"Baridwan","sequence":"first","affiliation":[{"name":"Department of Electrophysiology Heart and Diabetes Center NRW, Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Ger\u00e7ek","sequence":"additional","affiliation":[{"name":"Clinic For Cardiac Surgery and Pediatric Cardiac Surgery Herzzentrum Duisburg, Evangelische Kliniken Niederrhein GmbH  Duisburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Ger\u00e7ek","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, Angiology Herz\u2010 und Diabeteszentrum NRW, Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiel","family":"Morshuis","sequence":"additional","affiliation":[{"name":"Clinic For Thoracic and Cardiovascular Surgery Herz\u2010 und Diabeteszentrum NRW, Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Eitz","sequence":"additional","affiliation":[{"name":"Clinic For Thoracic and Cardiovascular Surgery Herz\u2010 und Diabeteszentrum NRW, Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Schramm","sequence":"additional","affiliation":[{"name":"Clinic For Thoracic and Cardiovascular Surgery Herz\u2010 und Diabeteszentrum NRW, Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, Angiology Herz\u2010 und Diabeteszentrum NRW, Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan F.","family":"Gummert","sequence":"additional","affiliation":[{"name":"Clinic For Thoracic and Cardiovascular Surgery Herz\u2010 und Diabeteszentrum NRW, Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart and Diabetes Center NRW, Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0490-5862","authenticated-orcid":false,"given":"Christian","family":"Sohns","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart and Diabetes Center NRW, Ruhr University Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelika","family":"Costard\u2010J\u00e4ckle","sequence":"additional","affiliation":[{"name":"Clinic For Thoracic and Cardiovascular Surgery Herz\u2010 und Diabeteszentrum NRW, Ruhr\u2010Universit\u00e4t Bochum  Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guram","family":"Imnadze","sequence":"additional","affiliation":[{"name":"Department of Electrophysiology Heart and Diabetes Center NRW, Ruhr University Bochum  Bad Oeynhausen Germany"},{"name":"Department of Rhythmology University Hospital Ruppin\u2010Brandenburg, Brandenburg Medical School Theodor Fontane  Neuruppin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,11]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab670"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1236"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2023.05.013"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.122.027251"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euz125"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.011813"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.16142"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.113.000457"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAT.0000000000000739"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1158248"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.15158"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaf129"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.3512"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2306037"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hroo.2021.09.005"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2024.131807"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.118.009091"}],"container-title":["Pacing 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