{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:03:22Z","timestamp":1784991802673,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:00:00Z","timestamp":1784937600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is increasingly conceptualized as a manifestation of atrial cardiomyopathy characterized by progressive fibrosis and structural remodeling. Systemic inflammation may contribute to AF progression and pathogenesis. Elevated inflammatory biomarkers may represent a pro\u2010inflammatory state, playing a possible role in AF. Left atrial (LA) scar burden serves as a surrogate for atrial fibrosis; however, its association with inflammatory markers is less well established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objectives of the study are as follows:<\/jats:p>\n                    <jats:p>To evaluate a possible association between LA scar burden and inflammatory markers.<\/jats:p>\n                    <jats:p>To identify additional markers correlated with higher scar burden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed patients undergoing first\u2010time AF ablation to explore the association between systemic inflammatory markers and LA scar burden. Biomarkers included high\u2010sensitivity C\u2010reactive protein (hsCRP), neutrophil\u2010to\u2010lymphocyte ratio (NLR), and N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP). Demographics, comorbidities, and CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc score were recorded. LA scar was quantified during electroanatomic voltage mapping using the BioSense Webster Oct array catheter D1609.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 229 patients with AF were included;107 (46.7%) demonstrated significant atrial scar, while 122 (53.3%) did not have significant scar burden. Of these, 147 patients with complete biomarker data were included in the final analysis. Scar\u2010present patients had significantly higher NT\u2010proBNP, hsCRP, and BMI, along with a higher prevalence of dyslipidemia, obstructive sleep apnoea, and hypothyroidism, and a significantly different AF type distribution (all\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). On univariable logistic regression, significant predictors of atrial scar included NT\u2010proBNP, BMI, hypothyroidism, Longstanding persistent Atrial Fibrillation (AF LS\u2010persistent), dyslipidemia, obstructive sleep apnea, and CHA\n                      <jats:sub>2<\/jats:sub>\n                      DS\n                      <jats:sub>2<\/jats:sub>\n                      \u2010VASc score, with hsCRP demonstrating a borderline association (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.076). On multivariable logistic regression, LS\u2010persistent AF was the only independent predictor of significant atrial scar (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.026), while BMI and hypothyroidism showed borderline independent associations (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.10).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest a possible correlation of inflammatory markers and Left Atrial scar burden. The association of other comorbidities, like higher BMI, hypothyroidism, dyslipidemia, and sleep apnea, with a higher atrial scar burden may be related to myocardial stress. This suggests an interplay of inflammatory markers and comorbidities, which result in a significant scar burden either directly or indirectly<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70374","type":"journal-article","created":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:59:13Z","timestamp":1784991553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiometabolic and Endocrine Correlates of Left Atrial Scar in Patients Undergoing Atrial Fibrillation Ablation"],"prefix":"10.1111","author":[{"given":"Atul","family":"Prakash","sequence":"first","affiliation":[{"name":"Department of Cardiology and Electrophysiology St Mary's General Hospital  Passaic New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-8507","authenticated-orcid":false,"given":"Kaushal","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine New York Medical College at St. Mary's General Hospital and St. Clare's Health  New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajitha Virinchipuram","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine New York Medical College at St. Mary's General Hospital and St. Clare's Health  New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0843-915X","authenticated-orcid":false,"given":"Gaurav","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology St Mary's General Hospital  Passaic New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darshan","family":"Gandhi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Electrophysiology St Mary's General Hospital  Passaic New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12077"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4901.101760"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065817"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/joa3.12895"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ\u201015\u20100138"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5511267"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.15420\/aer.2021.51"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8160393"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2020.00062"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.862164"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4022\/jafib.810"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1461923"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2022.0012"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2025.103193"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eux260"},{"issue":"32","key":"e_1_2_11_18_1","doi-asserted-by":"crossref","first-page":"53714","DOI":"10.18632\/oncotarget.16342","article-title":"Gender Differences in Fibrosis Remodeling in Patients With Longstanding Persistent Atrial Fibrillation","volume":"8","author":"Li Z.","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.15420\/usc.2017:39:1"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006077"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo16010059"},{"issue":"10","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.3390\/jcm13102895","article-title":"Association Between Obesity and Atrial Function in Patients With Non\u2010Valvular Atrial Fibrillation: An Echocardiographic Study","volume":"13","author":"Pucci M.","year":"2024","journal-title":"Journal of Clinical 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