{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:58:10Z","timestamp":1785391090578,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Objectives<\/jats:title>\n                    <jats:p>Right ventricular (RV) apical pacing, the standard pacing approach, often induces ventricular dyssynchrony, potentially impairing cardiac function. This study aims to investigate whether targeted RV septal pacing, guided by functional electrophysiological feedback during implantation, reduces ventricular dyssynchrony compared to conventional apical pacing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, observational study included 18 patients with standard pacing indications (second\u2010degree or intermittent third\u2010degree atrioventricular block, sinus node disease) undergoing dual chamber pacemaker implantation. Each patient initially underwent temporary transvenous RV apical pacing via femoral access, followed by permanent ventricular lead implantation using a functionally guided technique targeting the RV septum. Electrocardiographic (QRS duration) and echocardiographic parameters (septal\u2013posterior wall delay\u2014SPWD, interventricular mechanical delay\u2014IVMD) were measured at baseline, during RV apical pacing, and during targeted septal pacing. Comparisons were performed using paired within\u2010subject statistical analysis. Lead parameters and follow\u2010up data were also collected after implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>RV pacing significantly increased ventricular dyssynchrony parameters compared to baseline, regardless of lead position. Targeted RV septal pacing, however, resulted in significantly lower dyssynchrony than conventional RV apical pacing as quantified by QRS duration, SPWD and IVMD. No acute procedural complications were observed, and pacing lead parameters remained stable during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Targeted RV septal pacing, guided by electrophysiological criteria during implantation, was associated with significantly lower ventricular dyssynchrony than conventional apical pacing. These exploratory findings from an acute paired comparison suggest that functionally guided RV septal pacing may represent a practical alternative to conventional apical pacing and warrant confirmation in larger studies with long\u2010term clinical follow\u2010up.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70383","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T05:00:45Z","timestamp":1785387645000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ventricular Synchrony in Targeted Right Ventricular Septal Pacing: A Prospective Paired Comparison to Apical Placement"],"prefix":"10.1111","author":[{"given":"Bianca Iulia","family":"Catrina","sequence":"first","affiliation":[{"name":"County Clinical Emergency Hospital of Sibiu  Sibiu Romania"},{"name":"Pathophysiology Department Faculty of Medicine Lucian Blaga University of Sibiu  Sibiu Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9384-5584","authenticated-orcid":false,"given":"Mihai Octavian","family":"Negrea","sequence":"additional","affiliation":[{"name":"County Clinical Emergency Hospital of Sibiu  Sibiu Romania"},{"name":"Cardiology Department, Faculty of Medicine Lucian Blaga University of Sibiu  Sibiu Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ciprian","family":"T\u0103n\u0103sescu","sequence":"additional","affiliation":[{"name":"County Clinical Emergency Hospital of Sibiu  Sibiu Romania"},{"name":"Clinical Surgical Department, Faculty of Medicine Lucian Blaga University of Sibiu  Sibiu Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florina","family":"Batar","sequence":"additional","affiliation":[{"name":"County Clinical Emergency Hospital of Sibiu  Sibiu Romania"},{"name":"Physiology Pathophysiology Department, Faculty of Medicine Lucian Blaga University of Sibiu  Sibiu Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-0940","authenticated-orcid":false,"given":"Florin\u2010Leontin","family":"Lazar","sequence":"additional","affiliation":[{"name":"County Clinical Emergency Hospital of Sibiu  Sibiu Romania"},{"name":"Medical Clinic Number 1, 4th Department of Internal Medicine Iuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy  Cluj\u2010Napoca Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioan","family":"Manitiu","sequence":"additional","affiliation":[{"name":"County Clinical Emergency Hospital of Sibiu  Sibiu Romania"},{"name":"Cardiology Department, Faculty of Medicine Lucian Blaga University of Sibiu  Sibiu 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