{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:26:46Z","timestamp":1786980406012,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Conduction system pacing (CSP) is an emerging alternative modality of cardiac resynchronization therapy (CRT). However, not all patients obtain electrical resynchronization with CSP, there is a clinical need for reliable non\u2010invasive predictors of response. We aimed to assess the ability of several non\u2010invasive modalities to predict electrical resynchronization with CSP\u2010CRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with standard heart failure CRT indications (excluding right\u2010bundle branch block) underwent CSP\u2010CRT using His\u2010bundle and left\u2010bundle branch pacing. Electrical resynchronization was defined as a &gt;10\u00a0ms reduction in left ventricular activation time or conversion to a physiological left ventricular activation pattern on non\u2010invasive multi\u2010electrode mapping. We assessed whether 12\u2010lead ECG morphology, vector electrocardiogram (VCG) derived QRS area, Ultra High Frequency (UHF)\u2010ECG parameters or MRI scar burden predicted electrical resynchronization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty four patients were analyzed (mean age 69\u00b110 years; 82% male; LVEF 30\u00b16%; QRS duration 161\u00b123\u00a0ms; 32% ischemic cardiomyopathy). Electrical resynchronization was achieved in 24\/34 (71%; 95%CI 53\u201385). Strauss criteria positivity on 12\u2010lead ECG yielded a positive predictive value (PPV) of 83% (95%CI 61\u201395%) and negative predictive value (NPV) of 55% (95%CI 23\u201383%). VCG QRS area &gt;100\u00b5Vs demonstrated PPV 100% (95% CI 81\u2013100%) and NPV 73% (95%CI 85\u2013100%). UHF\u2010ECG e\u2010DYS &gt;50\u00a0ms gave PPV 93% (95%CI 66\u2013100%) and NPV 47% (23%\u201372%); &gt;60\u00a0ms gave PPV 90% (95%CI 66\u2013100%) and NPV 38% (95%CI 18\u201362%). MRI scar burden &lt;15% resulted in PPV 88% (95%CI 64\u201399%) and NPV 56% (95%CI 21\u201386%). Lines of propagation discontinuity on multi\u2010electrode mapping showed PPV 100% (95%CI 85\u2013100%) and NPV 83% (95%CI 52\u201398%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Multiple non\u2010invasive markers, including QRS morphology, VCG QRS area, UHF\u2010ECG e\u2010DYS, MRI scar burden showed potential to identify patients who are likely to electrically resynchronize with CSP\u2010CRT, although their NPVs were generally modest. Non\u2010invasive propagation mapping had the highest PPV and NPV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70393","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:49Z","timestamp":1786977949000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non\u2010Invasive Methods for Identifying Electrical Responders to Conduction System Pacing Cardiac Resynchronization Therapy"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9090-9610","authenticated-orcid":false,"given":"Jack W.","family":"Samways","sequence":"first","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3169-4776","authenticated-orcid":false,"given":"Nadine","family":"Ali","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7597-0170","authenticated-orcid":false,"given":"Ahran D.","family":"Arnold","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"},{"name":"Cardiology Department London North West University Healthcare NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Jian","family":"Chow","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Shun\u2010Shin","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jagdeep Singh","family":"Mohal","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akriti","family":"Naraen","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9385-9276","authenticated-orcid":false,"given":"Keenan","family":"Saleh","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Kaza","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4148-5000","authenticated-orcid":false,"given":"Chetanya","family":"Sharma","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Leinveber","sequence":"additional","affiliation":[{"name":"Institute of Scientific Instruments of the Czech Academy of Sciences  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-5075","authenticated-orcid":false,"given":"Pavel","family":"Jur\u00e1k","sequence":"additional","affiliation":[{"name":"Institute of Scientific Instruments of the Czech Academy of Sciences  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Keene","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5467-8958","authenticated-orcid":false,"given":"Yixiu","family":"Liang","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"},{"name":"Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, National Clinical Research Centre For Interventional Medicine Zhongshan Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3581-8078","authenticated-orcid":false,"given":"Nicholas S.","family":"Peters","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prapa","family":"Kanagaratnam","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Howard","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Qureshi","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu Siong","family":"Ng","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5712-849X","authenticated-orcid":false,"given":"Nick W.","family":"Linton","sequence":"additional","affiliation":[{"name":"Department of Bioengineering, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Lefroy","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrel P.","family":"Francis","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Boon","family":"Lim","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Tanner","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Muthumala","sequence":"additional","affiliation":[{"name":"Cardiology Department North Middlesex University Hospital NHS Trust  London UK"},{"name":"Cardiology Department, St Bartholomew's Hospital Barts Health NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8917-9032","authenticated-orcid":false,"given":"Frits W.","family":"Prinzen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M.","family":"Lubrecht","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cardiovascular Research Institute Maastricht Maastricht University  Maastricht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3523-6358","authenticated-orcid":false,"given":"Karol","family":"\u010curila","sequence":"additional","affiliation":[{"name":"Cardiocenter, Third Faculty of Medicine Charles University and University Hospital Kralovske Vinohrady  Prague Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Cole","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-5126","authenticated-orcid":false,"given":"Zachary","family":"Whinnett","sequence":"additional","affiliation":[{"name":"National Heart and Lung Institute, Imperial College London Hammersmith Hospital  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.026"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.09.073"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2020.04.037"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14681"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2016.07.013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038648"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.042453"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2024.01.038"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.11.010"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.013"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.eurheartj.a059647"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2015.04.001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelectrocard.2014.10.003"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14299"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf784.674"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euac245"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.14845"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554\u2010019\u201001620\u2010x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.06.016"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12904"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad043"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eul017"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad326"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eum133"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532\u2010429X\u201013\u201029"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt\u20102019\u2010001067"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.11.5"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.69.5.914"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0735\u20101097(86)80140\u20101"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1540\u20108167.2003.02421.x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.04.002"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095029.57483.60"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.111.095448"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.046"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.653568"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968\u2010019\u20100556\u20101"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac445"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70393","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:50Z","timestamp":1786977950000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":37,"alternative-id":["10.1111\/pace.70393"],"URL":"https:\/\/doi.org\/10.1111\/pace.70393","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,17]]},"assertion":[{"value":"2026-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pace.70393"}}