{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T07:08:26Z","timestamp":1789110506109,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004480","name":"Natural Science Foundation of Shanxi Province","doi-asserted-by":"publisher","award":["20210302123346"],"award-info":[{"award-number":["20210302123346"]}],"id":[{"id":"10.13039\/501100004480","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>In pulsed field ablation (PFA), adequate catheter\u2010tissue contact is crucial as it can effectively reduce the occurrence of hemolysis. Activation of the tissue proximity\u2010indicating (TPI) function ensures effective catheter\u2010tissue apposition. However, to date, no relevant clinical studies have been reported on the correlation between TPI function activation and hemolysis during PFA for atrial fibrillation (AF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate in depth the correlation between the \u201cTPI\u201d function of catheters and postoperative hemolysis following pulsed field ablation (PFA) for atrial fibrillation (AF) from hematological and pathological perspectives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>By applying PFA treatment in both TPI\u2010ON and TPI\u2010OFF modes to isolated porcine atrial myocardial tissue and in situ atrial myocardium from six pigs, the effects on hemolysis were observed under these two scenarios.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In vitro, plasma free hemoglobin (fHb) increased with the number of applications and was lower with TPI\u2010ON than with TPI\u2010OFF at matched application numbers (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05). In vivo, both groups achieved transmural lesions with comparable lesion depth. Mean fHb values at 5 and 30\u00a0min were numerically lower with TPI\u2010ON, but the group\u2010by\u2010time interaction was not significant (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.153). CK and CK\u2010MB increased transiently within 24\u00a0h, whereas urea and creatinine showed no consistent between\u2010group pattern; none of the four biochemical group\u2010by\u2010time interactions remained significant after Holm correction. Renal histology showed no irreversible parenchymal injury in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this preclinical model, use of the impedance\u2010based TPI function was associated with lower post\u2010PFA hemolysis while preserving acute transmural lesion formation. These findings support further validation of TPI\u2010guided catheter positioning in clinical studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70398","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:56:27Z","timestamp":1789109787000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TPI Function in Pulsed Field Ablation for Atrial Fibrillation: Hemolysis Control and Organ Protection"],"prefix":"10.1111","author":[{"given":"Rui","family":"Yan","sequence":"first","affiliation":[{"name":"The First Clinical Medical College Shanxi Medical University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1936-8406","authenticated-orcid":false,"given":"Fanqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Xiangya Hospital of Central South University  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Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6179-8472","authenticated-orcid":false,"given":"Chunrong","family":"Jin","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Shanxi Medical University  Taiyuan China"},{"name":"Shanxi Provincial Clinical Research Center for Interventional Medicine  Taiyuan 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