{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:09:55Z","timestamp":1789531795892,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mechanisms underlying cardiac manifestations of immune\u2010mediated congenital complete heart block (CCHB) remain unclear. Dilated cardiomyopathy (DCM) in immune\u2010mediated CCHB has been associated with RV pacing, whereas reports of LV pacing\u2010associated DCM are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case summary<\/jats:title>\n                    <jats:p>A girl with immune\u2010mediated CCHB showed endocardial fibroelastosis (EFE) at 20 weeks of gestation before heart block developed at 22 weeks. After LV basal\u2010lateral pacing, she developed DCM with LV dyssynchrony. Cardiac resynchronization therapy (CRT) improved LV function and induced reverse remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Myocardial injury may precede conduction system involvement in immune\u2010mediated CCHB. Subclinical immune\u2010mediated myocardial vulnerability and pacing\u2010related dyssynchrony may contribute to DCM progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70437","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:58:26Z","timestamp":1789531106000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Left Ventricular Pacing\u2010Associated Cardiomyopathy Revealing Myocardial Vulnerability in Congenital Complete Heart Block"],"prefix":"10.1111","author":[{"given":"Sachie","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Pediatrics Seirei Hamamatsu General Hospital  Hamamatsu Japan"},{"name":"Department of Pediatric Cardiology Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-9378","authenticated-orcid":false,"given":"Aya","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Seirei Hamamatsu General Hospital  Hamamatsu Japan"},{"name":"Department of Adult Congenital Heart Disease Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Seirei Hamamatsu General Hospital  Hamamatsu Japan"},{"name":"Department of Adult Congenital Heart Disease Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2494-6848","authenticated-orcid":false,"given":"Minori","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Seirei Hamamatsu General Hospital  Hamamatsu Japan"},{"name":"Department of Surgery, Cardiovascular Surgery Yokohama City University Hospital  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Koide","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1785-9127","authenticated-orcid":false,"given":"Hiroki","family":"Uchiyama","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Seirei Hamamatsu General Hospital  Hamamatsu Japan"},{"name":"Department of Adult Congenital Heart Disease Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumi","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Seirei Hamamatsu General Hospital  Hamamatsu Japan"},{"name":"Department of Adult Congenital Heart Disease Seirei Hamamatsu General Hospital  Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ccl.2023.03.002","article-title":"Congenital Heart Block","volume":"41","author":"Steinberg L.","year":"2023","journal-title":"Cardiology Clinics"},{"issue":"1","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.yexcr.2014.01.003","article-title":"Wahren\u2010Herlenius M. 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