{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:03:32Z","timestamp":1790215412410,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Partially anomalous pulmonary vein return (PAPVR) is a heterogeneous group of congenital heart defects. Here, we describe a 51\u2010year\u2010old patient with corrected PAPVR (cPAPVR) and atrioventricular canal defect who presented for AFL ablation. The right pulmonary veins were isolated, and the OP was heterogeneously fibrotic. Three left AFL and one cavo\u2010tricuspid isthmus (CTI)\u2010dependent AFL were induced and mapped using activation and Ablation at each site terminated the AFL. Subsequently, the entire OP was isolated. Post\u2010ablation, she had no atrial arrhythmia at 6 months follow up. Genetic testing identified a pathological mutation in the TBX5 gene, consistent with Holt\u2010Oram syndrome.<\/jats:p>","DOI":"10.1111\/pace.70442","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:26:12Z","timestamp":1790213172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atrial Flutter in Partially Anomalous Pulmonary Venous Return: Electrophysiological Insights in Holt\u2010Oram Syndrome"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1005-9690","authenticated-orcid":false,"given":"Marinos","family":"Kosmopoulos","sequence":"first","affiliation":[{"name":"Division of Cardiology The Johns Hopkins Hospital Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babken","family":"Asatryan","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology The Johns Hopkins Hospital Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Barth","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology The Johns Hopkins Hospital Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Doshi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology The Johns Hopkins Hospital Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachariah","family":"Hale","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology The Johns Hopkins Hospital Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Cedars","sequence":"additional","affiliation":[{"name":"Division of Cardiology The Johns Hopkins Hospital Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"Division of Pediatric Cardiology The Johns Hopkins Hospital Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos N.","family":"Aronis","sequence":"additional","affiliation":[{"name":"Section of Cardiac Electrophysiology The Johns Hopkins Hospital Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association","volume":"149","author":"Martin S. S.","year":"2024","journal-title":"Circulation"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1161\/CIRCULATIONAHA.106.627224","article-title":"Congenital Heart Disease in the General Population: Changing Prevalence and Age Distribution","volume":"115","author":"Marelli A. J.","year":"2007","journal-title":"Circulation"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2022.05.008"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/joa3.12308","article-title":"2019APHRS Expert Consensus Statement on Three\u2010Dimensional Mapping Systems for Tachycardia Developed in Collaboration With HRS, EHRA, and LAHRS","volume":"36","author":"Kim Y.","year":"2020","journal-title":"Journal of Arrhythmia"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728\u2010200309000\u201000011"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1161\/CIRCULATIONAHA.112.104786","article-title":"Sudden Cardiac Death in Adult Congenital Heart Disease","volume":"126","author":"Koyak Z.","year":"2012","journal-title":"Circulation"},{"key":"e_1_2_10_8_1","first-page":"1472","article-title":"Atypical Atrial Flutter After Surgical Correction of Anomalous Pulmonary Venous Return","volume":"4","author":"Ismail H.","year":"2013","journal-title":"Journal of Innovations in Cardiac Rhythm Management"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0735-1097(01)01392-4","article-title":"Coexistence of Type I Atrial Flutter and Intra\u2010Atrial Re\u2010Entrant Tachycardia in Patients With Surgically Corrected Congenital Heart Disease","volume":"38","author":"Akar J. G.","year":"2001","journal-title":"Journal of the American College of Cardiology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2004.10.034"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2021.101179"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.16"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3892\/mmr.2022.12726","article-title":"TBX5 variant With the Novel Phenotype of Mixed\u2011Type Total Anomalous Pulmonary Venous Return in Holt\u2011Oram Syndrome and Variable Intrafamilial Heart Defects","volume":"25","author":"Azab B.","year":"2022","journal-title":"Molecular Medicine Reports"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:26:13Z","timestamp":1790213173000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":12,"alternative-id":["10.1111\/pace.70442"],"URL":"https:\/\/doi.org\/10.1111\/pace.70442","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"2025-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pace.70442"}}