{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:51:43Z","timestamp":1791993103554,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pacing Clinical Electrophis"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Permanent pacemaker implantation is a common complication after transcatheter aortic valve replacement (TAVR). Leadless pacemakers (LPs) may reduce lead\u2010 and pocket\u2010related complications, but their clinical outcomes after TAVR remain uncertain. This systematic review and meta\u2010analysis evaluated the safety and effectiveness of LPs compared with transvenous pacemakers (TVPs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Scopus, and ScienceDirect were searched from inception to June 10, 2026. Randomized and observational studies were included. Random\u2010effects meta\u2010analyses pooled proportions, risk ratios (RRs), and mean differences (MDs). Reconstructed Kaplan\u2013Meier data were used to estimate hazard ratios (HRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ten studies involving 10,809 patients (1030 LP and 9779 TVP recipients) were included. The pooled procedural success rate of LP implantation was 98% (95% CI 95%\u201399%). Implantation success was comparable between LP and TVP (RR 1.00, 95% CI 0.98\u20131.02). Sensitivity analysis demonstrated a shorter hospital stay with LP (MD \u22121.37 days, 95% CI \u22122.33 to \u22120.41) and a lower risk of heart failure hospitalization (RR 0.37, 95% CI 0.14\u20130.96). Overall survival did not differ between groups (HR 1.05, 95% CI 0.44\u20131.23), although reconstructed survival curves showed late separation favoring LP. Device\u2010related and vascular complications were comparable between LP and TVP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LP implantation after TAVR demonstrates excellent procedural success and clinical outcomes comparable to TVPs. LPs may reduce hospital stay and heart failure hospitalization, supporting their use as an alternative pacing strategy in appropriately selected patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pace.70468","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:36:46Z","timestamp":1791992206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leadless Pacemakers After Transcatheter Aortic Valve Replacement: A Meta\u2010analysis With Time\u2010to\u2010Event Analysis"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0308-6141","authenticated-orcid":false,"given":"Frengki Prabowo Saputro","family":"Wijayanto","sequence":"first","affiliation":[{"name":"Department of Medicine Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4105-8739","authenticated-orcid":false,"given":"Christopher Daniel","family":"Tristan","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Universitas Sebelas Maret  Solo Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4799-385X","authenticated-orcid":false,"given":"Muhammad Reva","family":"Aditya","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine Universitas Brawijaya  Malang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0653-634X","authenticated-orcid":false,"given":"Artha Maressa Theodora","family":"Simanjuntak","sequence":"additional","affiliation":[{"name":"Department of Medicine Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3998-6551","authenticated-orcid":false,"given":"Raymond","family":"Pranata","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Pelita Harapan  Tangerang Indonesia"},{"name":"Department of Cardiovascular Medicine Siloam Hospitals Lippo Village  Tangerang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028352"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx785"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.08.050"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511643"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab767"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2026.03.017"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_10_1","unstructured":"J.Higgins J.Thomas J.Chandler et\u00a0al. \u201cCochrane Handbook for Systematic Reviews of Interventions Version 6.5 \u201d (updated August 2024) (Cochrane 2024)."},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14702"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjco.2023.10.009"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2024.01.005"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2026.02.004"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.14545"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.13648"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.25270\/jic\/20.00076"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.19102\/icrm.2023.14062"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2024.05.030"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaf264"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.11.008"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.01.035"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.03.019"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2017.05.017"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643\u2010025\u201002752\u2010z"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3623"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102288\u201013\u2010152"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.02.003"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euad025"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2025.03.028"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/pace.70299"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jce.15863"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euae273"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2019.10.017"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2018.05.004"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2020.07.024"}],"container-title":["Pacing and Clinical Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70468","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pace.70468","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pace.70468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:36:47Z","timestamp":1791992207000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pace.70468"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":35,"alternative-id":["10.1111\/pace.70468"],"URL":"https:\/\/doi.org\/10.1111\/pace.70468","archive":["Portico"],"relation":{},"ISSN":["0147-8389","1540-8159"],"issn-type":[{"value":"0147-8389","type":"print"},{"value":"1540-8159","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"assertion":[{"value":"2026-09-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pace.70468"}}