{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:38:27Z","timestamp":1792471107437,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnostic gold standard of food allergy is the oral food challenge (<jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>). Data on severe reactions and drug use during <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> are scarce. Our aims were (i) to investigate the prevalence and spectrum of reactions' severity during <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> and to assess drug use and epinephrine use in anaphylaxis due to <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>; (ii) to investigate the predictive value of the skin prick test wheal size for the outcome of <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective charts review of children undergoing <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content> at three <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>llergy <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>entres between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>anuary 2007 and <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ecember 2008 was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 544 <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>s were analysed. Most frequently involved foods were egg, milk and wheat. 254\/526 (48.3%) were positive. 167 (65.7%) were defined mild reactions, 81 (31.9%) multiorgan reactions and 6 (2.4%) anaphylaxis. No patients had cardiovascular symptoms. Data on treatments were available in 98.8% <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>s. In half of them antihistamines were used vs. 10% cases in which steroids were preferred. Six children (2.4%) were treated with Epinephrine inhalation, 5 (2%) with beta\u20102 inhalation, 8 (3.1%) with steroid inhalation. One child was treated with <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> Epinephrine\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> fluids. Skin prick tests predictive cut\u2010off were 9\u00a0mm for albumen, 7 for yolk, 13 for fresh albumen, 10 for \u03b1\u2010lactalbumin, seven for casein, eight for \u03b2\u2010lactoglobulin, 20 for cow's milk and 10 for fresh cow's milk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OFCs performed in controlled settings by expert <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>llergists are safe. Consideration needs to be given as to whether the <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>naphylaxis' <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>uideline need to be modified when applied in treating patients undergoing <jats:styled-content style=\"fixed-case\">OFC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12016","type":"journal-article","created":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T17:47:39Z","timestamp":1351532859000},"page":"754-760","source":"Crossref","is-referenced-by-count":53,"title":["Oral food challenge: safety, adherence to guidelines and predictive value of skin prick testing"],"prefix":"10.1111","volume":"23","author":[{"given":"Mauro","family":"Calvani","sequence":"first","affiliation":[{"name":"Department of Pediatrics S. Camillo\u2010Forlanini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Berti","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health IRCCS \u201cBurlo Garofolo\u201d Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Fiocchi","sequence":"additional","affiliation":[{"name":"Paediatric Division Department of Child and Maternal Medicine University of Milan Medical School at Melloni Hospital Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Galli","sequence":"additional","affiliation":[{"name":"Research Center S. Pietro Hospital Fatebenefratelli Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Giorgio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Martelli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics S. Corona Hospital Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Miceli Sopo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Catholic University of Sacred Heart Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Panetta","sequence":"additional","affiliation":[{"name":"L'altrastatistica srl Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.08.028"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.02.001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01145.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-37-53"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2000.00689.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.jaci.2004.07.063","article-title":"Risk of oral challenges","volume":"114","author":"Perry T","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)60473-5"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.07.012"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01421.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.01.038"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.114708"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2004.00188.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00928.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(88)90135-2"},{"key":"e_1_2_5_16_1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1111\/j.1398-9995.2004.00466.x","article-title":"Standardization of food challenges in patients with immediate reactions to foods \u2013 position paper from the European Academy of Allergology and Clinical Immunology","volume":"59","author":"Bindslev\u2010Jensen C","year":"2004","journal-title":"Allergy"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01200.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.006"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e32834694d8"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.049"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000136762.89313.0b"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1754.2003.00157.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.009"},{"key":"e_1_2_5_24_1","first-page":"18","article-title":"A new model for conservative food challenge in children with immunoglobulin E\u2010mediated cow's milk allergy","volume":"14","author":"Calvani M","year":"2012","journal-title":"Isr J Med"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.030"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1998.tb00371.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.003"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03299.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2011.01237.x"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2745.2002.01454.x"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2007.00564.x"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12016","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T14:21:59Z","timestamp":1697293319000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,29]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/pai.12016"],"URL":"https:\/\/doi.org\/10.1111\/pai.12016","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,29]]}}}