{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:07:40Z","timestamp":1779170860430,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple drug hypersensitivity (<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>) has been defined as a hypersensitivity to two or more chemically different drugs. Two types of<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>have been reported: the first one, which develops to different drugs administered simultaneously and the second type, in which sensitizations develop sequentially. In children, studies which diagnose<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>on the basis of positive allergologic tests to 2 or more chemically different drugs are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective study evaluating children with histories of<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>by skin tests, patch tests, serum\u2010specific IgE assays, and drug provocation tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>was diagnosed in 7 (2.5%) of the 279 children evaluated who completed the study. The responsible drugs were \u03b2\u2010lactams (penicillins and cephalosporins) in 5 episodes, ibuprofen and anticonvulsants in 3, and erythromycin, fentanyl, methylprednisolone, and cotrimoxazole in 1. Sensitivity to 2 chemically different drugs was diagnosed in 6 children and to 3 drugs in 1 child. Two of the 7 children presented the first type of<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>, whereas 5 displayed the second one.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>can occur in children, even to drugs other than antibiotics. It is crucial to evaluate children with histories of<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>using both<jats:italic>in vivo<\/jats:italic>and<jats:italic>in vitro<\/jats:italic>allergologic tests, including challenges. In fact, such approach allows the physician to confirm the diagnosis of<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>in a small percentage of children with histories of<jats:styled-content style=\"fixed-case\">MDH<\/jats:styled-content>, as well as to rule it out in the great majority of them.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12020","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T03:06:13Z","timestamp":1354244773000},"page":"785-791","source":"Crossref","is-referenced-by-count":27,"title":["Diagnosing multiple drug hypersensitivity in children"],"prefix":"10.1111","volume":"23","author":[{"given":"Marina","family":"Atanaskovi\u0107\u2010Markovi\u0107","sequence":"first","affiliation":[{"name":"Department of Allergology and Pulmonology University Children's Hospital Belgrade Serbia"},{"name":"Medical Faculty University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Gaeta","sequence":"additional","affiliation":[{"name":"Allergy Unit Complesso Integrato Columbus Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Gavrovi\u0107\u2010Jankulovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Chemistry University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja","family":"\u010cirkovi\u0107 Veli\u010dkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Chemistry University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco Luigi","family":"Valluzzi","sequence":"additional","affiliation":[{"name":"Allergy Unit Complesso Integrato Columbus Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Romano","sequence":"additional","affiliation":[{"name":"Allergy Unit Complesso Integrato Columbus Rome Italy"},{"name":"IRCCS Oasi Maria S.S. 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