{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:12:59Z","timestamp":1772223179058,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T00:00:00Z","timestamp":1358640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We have previously reported patch test reactivity to nickel sulphate in a cohort of unselected infants tested repeatedly at 3\u201318\u00a0months of age. A reproducible positive reaction at 12 and 18\u00a0months was selected as a sign of nickel sensitivity provided a patch test with an empty Finn chamber was negative. A reproducible positive reaction was seen in 8.6% of the infants. The objective of this study is to follow\u2010up on infants with alleged nickel sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 562 infants were included in the cohort and patch tested with nickel sulphate (<jats:styled-content style=\"fixed-case\">ICDRG<\/jats:styled-content> guidelines). The 26 children with a positive patch test reaction to nickel sulphate at 12 and 18\u00a0months were offered repeated patch tests at 3 and 6\u00a0yr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 21 children tested at both 12\u00a0months, 18\u00a0months and at 3 and 6\u00a0yr only 2 of 21 had reproducible nickel reactions (one clinically relevant), 13 of 21 were negative and 6 of 21 were negative at 3 or 6\u00a0yr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Only 9.5% of the children had reproducible nickel sulphate reactivity, while 62% became negative. The results are noteworthy and can be interpreted in different ways: Repeated nickel patch tests did not cause patch test sensitization. The test reactions in infancy are probably of irritant or non\u2010specific nature. Hence, nickel patch tests should only be performed in small children if there is a clinical suspicion of nickel\u2010induced allergic contact dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12027","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T03:09:51Z","timestamp":1358737791000},"page":"84-87","source":"Crossref","is-referenced-by-count":28,"title":["Positive nickel patch tests in infants are of low clinical relevance and rarely reproducible"],"prefix":"10.1111","volume":"24","author":[{"given":"Charlotte G.","family":"Mortz","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik F.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esben","family":"Eller","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Osterballe","sequence":"additional","affiliation":[{"name":"The Dermatology Clinic Herning Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lene A.","family":"Norberg","sequence":"additional","affiliation":[{"name":"Department of Health Odense City Government and Administration Odense S\u00f8 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"H\u00f8st","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children's Hospital Odense University Hospital University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital University of Southern Denmark Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00425.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555924447"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247298"},{"key":"e_1_2_6_5_1","unstructured":"JohansenJD FroschPJ LepoittevinJP. 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