{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:50:55Z","timestamp":1791571855918,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,1,20]],"date-time":"2013-01-20T00:00:00Z","timestamp":1358640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mometasone furoate nasal spray (<jats:styled-content style=\"fixed-case\">MFNS<\/jats:styled-content>) improves nasal symptoms and reduces polyp size in adults with nasal polyposis. This 4\u2010month, multinational, randomized, double\u2010blind study was conducted to assess the safety of <jats:styled-content style=\"fixed-case\">MFNS<\/jats:styled-content> in pediatric subjects aged 6\u201317\u00a0yr.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects aged 6\u201311\u00a0yr with bilateral nasal polyps received <jats:styled-content style=\"fixed-case\">MFNS<\/jats:styled-content> 100\u00a0\u03bcg once or twice daily or placebo; those aged 12\u201317\u00a0yr received <jats:styled-content style=\"fixed-case\">MFNS<\/jats:styled-content> 200\u00a0\u03bcg once or twice daily or placebo. End\u2010points included change in 24\u2010h urinary free cortisol (primary), change in 24\u2010h urinary free cortisol corrected for creatinine (key secondary), and adverse events. Efficacy parameters included polyp size, nasal symptoms, and investigator\u2010evaluated therapeutic response, although the study was not powered for statistical analysis of efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Least squares baseline mean urinary free cortisol level (nmol\/24\u00a0h) for both age groups combined (N\u00a0=\u00a0127) was 49.5 in the <jats:styled-content style=\"fixed-case\">MFNS<\/jats:styled-content> once\u2010daily group, 39.6 in the <jats:styled-content style=\"fixed-case\">MFNS<\/jats:styled-content> twice\u2010daily group, and 49.8 in the placebo group. Change in 24\u2010h urinary free cortisol did not significantly differ among <jats:styled-content style=\"fixed-case\">MFNS<\/jats:styled-content>\u2010 and placebo\u2010treated subjects. Least squares mean 24\u2010h urinary free cortisol levels corrected for creatinine also showed no significant differences among <jats:styled-content style=\"fixed-case\">MFNS<\/jats:styled-content>\u2010 and placebo\u2010treated subjects. No safety issues emerged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results of this study confirm the safety profile of <jats:styled-content style=\"fixed-case\">MFNS<\/jats:styled-content> in pediatric patients with bilateral nasal polyps over 4\u00a0months, even at double the recommended pediatric dosage for allergic rhinitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12032","type":"journal-article","created":{"date-parts":[[2013,1,21]],"date-time":"2013-01-21T03:09:51Z","timestamp":1358737791000},"page":"33-38","source":"Crossref","is-referenced-by-count":23,"title":["Safety of mometasone furoate nasal spray in the treatment of nasal polyps in children"],"prefix":"10.1111","volume":"24","author":[{"given":"Victor","family":"Chur","sequence":"first","affiliation":[{"name":"Instituto de Alergias y Enfermedades Respiratorias Guatemala City Guatemala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine B.","family":"Small","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine New York Medical College Westchester Medical Center Valhalla NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Stryszak","sequence":"additional","affiliation":[{"name":"Merck Sharpe &amp; Dohme Corp. 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