{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:11:21Z","timestamp":1790154681622,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hypersensitivity reactions to non\u2010steroidal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) are the most frequently reported reaction to drugs. They can be induced by pharmacological mechanisms (cyclooxygenase inhibition), with patients classified as cross\u2010intolerant (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>), or by specific immunological mechanisms, <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> cell, with patients classified as selective reactors (<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse a large group of children with a history of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> hypersensitivity diagnosed by drug provocation test (<jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A group of 63 children with a history of <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content> hypersensitivity were evaluated by <jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content>. The children were classified as <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> depending on the acetyl salicylic acid (<jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>) response in <jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content>. The atopic status was also assessed by prick tests and total <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> in serum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using <jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content>, 68.2% were confirmed as having hypersensitivity, 58.1% classified as <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> and 41.9% as <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>. Of the 119 DPT performed, 73 were positive (53.4% to ibuprofen, 37% to ASA, 8.2% to metamizol and 14% to paracetamol); angio\u2010oedema was present in 86.3% of cases. All <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> cases tolerated the administration of paracetamol. A significant number of the <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> children were atopic compared with the <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> children and non\u2010allergic controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In these children, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> hypersensitivity to <jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s was the most frequent type of hypersensitivity reaction. Ibuprofen was the drug most often involved, angio\u2010oedema the most common entity, and frequently associated with atopy. <jats:styled-content style=\"fixed-case\">DPT<\/jats:styled-content> proved a safe approach for diagnosing these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12039","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T05:43:50Z","timestamp":1363671830000},"page":"151-159","source":"Crossref","is-referenced-by-count":77,"title":["Drug provocation tests in the diagnosis of hypersensitivity reactions to non\u2010steroidal anti\u2010inflammatory drugs in children"],"prefix":"10.1111","volume":"24","author":[{"given":"Maria A.","family":"Zambonino","sequence":"first","affiliation":[{"name":"Pediatric Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Torres","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candelaria","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Pediatric Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Requena","sequence":"additional","affiliation":[{"name":"Pediatric Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristobalina","family":"Mayorga","sequence":"additional","affiliation":[{"name":"Pediatric Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Posadas","sequence":"additional","affiliation":[{"name":"Pediatric Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Urda","sequence":"additional","affiliation":[{"name":"Pediatric Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Blanca","sequence":"additional","affiliation":[{"name":"Allergy Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Corzo","sequence":"additional","affiliation":[{"name":"Pediatric Service Carlos Haya Hospital Malaga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,18]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"363","article-title":"Drug hypersensitivity reactions: patterns of responses, drug involved and temporal variation in a large series of patients evaluated","volume":"22","author":"Do\u00f1a I","year":"2012","journal-title":"J Invest Allergol Clin Immunol"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03651.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-05659-5.00069-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2710.2012.01359.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2001.00002.x-i1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2003.163"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03237.x"},{"key":"e_1_2_9_9_1","first-page":"295","article-title":"Angioedema and IgE antibodies to aspirin: a case report","volume":"62","author":"Blanca M","year":"1989","journal-title":"Ann Allergy"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2003.12.323"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1980.tb01730.x"},{"key":"e_1_2_9_12_1","first-page":"1747","volume-title":"Allergy: Principles and Practice","author":"Stevenson DD","year":"1993"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000337660"},{"key":"e_1_2_9_14_1","first-page":"114","article-title":"Nonsteroidal anti inflammatory drug hypersensitivity in preschool children","volume":"3","author":"Kidon MI","year":"2007","journal-title":"Allergy Asthma Clin Immunol"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.2004.00159.x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.4.e39"},{"key":"e_1_2_9_17_1","first-page":"265","article-title":"Aspirin\u2010induced recurrent urticaria and recurrent angioedema in non\u2010atopic children","volume":"53","author":"Botey J","year":"1984","journal-title":"Ann Allergy"},{"key":"e_1_2_9_18_1","first-page":"277","article-title":"NSAID facial angioedema in a selected pediatric atopic population","volume":"10","author":"Capriles\u2010Behrens E","year":"2000","journal-title":"J Invest Allergol Clin Immunol"},{"key":"e_1_2_9_19_1","first-page":"43","article-title":"Acetyl salicylic acid\u2010induced urticaria and\/or angioedema in atopic children","volume":"16","author":"Botey J","year":"1988","journal-title":"Allergol Immunopathol"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.018001066.x"},{"key":"e_1_2_9_21_1","first-page":"561","article-title":"Hypersensitivity to cyclooxygenase inhibitory drugs in children: a study of 164 cases","volume":"18","author":"Hassani A","year":"2008","journal-title":"Eur J Dermatol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2005-0969"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00855.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03995.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)62748-2"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2003.00279.x"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12013"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01903.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.024"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(96)70102-1"},{"key":"e_1_2_9_31_1","first-page":"139","article-title":"Increased total and mite\u2010specific immunoglobulin E in patients with aspirin\u2010induced urticaria and angioedema","volume":"20","author":"Sanchez\u2010Borges M","year":"2010","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)61782-6"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.2500\/ar.2012.3.0025"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.10.002"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1329"},{"key":"e_1_2_9_36_1","first-page":"3","article-title":"Possible interaction among hypersensitivity to lipid transfer proteins, chronic urticaria, and hypersensitivity reactions to nonsteroidal anti\u2010inflammatory drugs","volume":"43","author":"Romano A","year":"2011","journal-title":"Eur Ann Allergy Clin Immunol"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04329.x"}],"container-title":["Pediatric Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpai.12039","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pai.12039","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T06:18:07Z","timestamp":1697264287000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pai.12039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["10.1111\/pai.12039"],"URL":"https:\/\/doi.org\/10.1111\/pai.12039","archive":["Portico"],"relation":{},"ISSN":["0905-6157","1399-3038"],"issn-type":[{"value":"0905-6157","type":"print"},{"value":"1399-3038","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}