{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:33:09Z","timestamp":1783686789595,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The yeast M<\/jats:styled-content>alassezia<\/jats:italic> belongs to our normal cutaneous flora, but is capable of sensitizing individuals with atopic dermatitis (AD<\/jats:styled-content>). Our objective was to investigate the prevalence of sensitization to M<\/jats:styled-content>alassezia<\/jats:italic> with a 10\u2010yr follow\u2010up among children suffering from AD<\/jats:styled-content> combined with food allergy (FA<\/jats:styled-content>) in relation to the extent of AD<\/jats:styled-content> in infancy.<\/jats:p><\/jats:sec>Methods<\/jats:title>One hundred and eighty seven infants diagnosed with AD<\/jats:styled-content> and milk\/wheat allergy before 1\u00a0yr of age were included in the study. The area of AD<\/jats:styled-content> was estimated from patient records of the first visit and measured with SCORAD<\/jats:styled-content> at the 10\u2010yr follow\u2010up. Specific I<\/jats:styled-content>gE<\/jats:styled-content> against M<\/jats:styled-content>alassezia<\/jats:italic> was determined with I<\/jats:styled-content>mmunoCAP<\/jats:styled-content>\u2122 at 11\u00a0yr of age.<\/jats:p><\/jats:sec>Results<\/jats:title>In infancy, 24 children (13%) were allergic to milk, 71 (38%) to wheat, and 92 (49%) to both milk and wheat, and 94 (50%) children had mild, 57 (30%) moderate and 36 (19%) severe AD<\/jats:styled-content>. At the 10\u2010yr follow\u2010up visit, 19 (10%) of the children had ongoing milk and\/or wheat allergy; 147 children (79%) had mild AD<\/jats:styled-content> and 30 (16%) had SCORAD<\/jats:styled-content> index of 0. Specific I<\/jats:styled-content>gE<\/jats:styled-content> against M<\/jats:styled-content>alassezia<\/jats:italic> mix was positive (\u22650.35\u00a0kU\/l) in 27% and specific I<\/jats:styled-content>gE<\/jats:styled-content> against M<\/jats:styled-content>.\u00a0sympodialis<\/jats:italic> in 20% of the 187 children. The area of AD<\/jats:styled-content> in infancy was associated with a greater risk of having allergen\u2010specific I<\/jats:styled-content>gE<\/jats:styled-content> to M<\/jats:styled-content>alassezia<\/jats:italic> at the 10\u2010yr follow\u2010up. The risk ratio for FA<\/jats:styled-content> was 3.11 (95% CI<\/jats:styled-content>: 2.05\u20134.72; p\u00a0<\u00a00.001) if specific I<\/jats:styled-content>gE<\/jats:styled-content> to M<\/jats:styled-content>alassezia<\/jats:italic> was positive.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Infants with severe AD<\/jats:styled-content> and FA<\/jats:styled-content> seem to have a greater risk of becoming sensitized to M<\/jats:styled-content>alassezia<\/jats:italic> during a 10\u2010yr follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12057","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T06:16:55Z","timestamp":1364969815000},"page":"244-249","source":"Crossref","is-referenced-by-count":20,"title":["Sensitization to M<\/scp>alassezia<\/i> in children with atopic dermatitis combined with food allergy"],"prefix":"10.1111","volume":"24","author":[{"given":"O\u2010M.","family":"Kekki","sequence":"first","affiliation":[{"name":"Allergy Unit Department of Dermatology Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Scheynius","sequence":"additional","affiliation":[{"name":"Translational Immunology Unit Department of Medicine Solna Karolinska Institutet and University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Poikonen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Central Finland Central Hospital Jyv\u00e4skyl\u00e4 Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Koskinen","sequence":"additional","affiliation":[{"name":"Allergy Unit Department of Dermatology Tampere University Hospital Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kautiainen","sequence":"additional","affiliation":[{"name":"Unit of Primary Health Care Helsinki University Central Hospital Helsinki 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