{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:00:17Z","timestamp":1772690417339,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T00:00:00Z","timestamp":1364947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children with atopic diseases in early life are frequently found with positive <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> tests to peanuts\/tree nuts without a history of previous ingestion. We aimed to identify risk factors for reactions to nuts at first introduction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case\u2010note and database analysis was performed. Recruitment criteria were: patients aged 3\u201316\u00a0yr who had a standardized food challenge to peanut and\/or tree nuts due to sensitisation to the peanut\/tree nut (positive spIg<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">SPT<\/jats:styled-content>) without previous consumption. A detailed assessment was performed of factors relating to food challenge outcome with univariate and multivariate logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 98 food challenges (47 peanut, 51 tree nut) with 29 positive, 67 negative and 2 inconclusive outcomes. A positive maternal history of allergy and a specific <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> &gt;5\u00a0k<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\/l were strongly associated with a significantly increased risk of a positive food challenge (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.73; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.31\u201310.59; p\u00a0=\u00a00.013 and <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.35; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.23\u20139.11; p\u00a0=\u00a00.007, respectively). Adjusting for age, a three year\u2010old with these criteria has a 67% probability of a positive challenge. There was no significant association between types of peanut\/tree nut, other food allergies, atopic conditions or severity of previous food reactions and positive challenges.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We have demonstrated an association between the presence of maternal atopic history and a specific <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">E<\/jats:styled-content> &gt;5\u00a0k<jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>\/l, with a significant increase in the likelihood of a positive food challenge. Although requiring further prospective validation these easily identifiable components should be considered when deciding the need for a challenge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12059","type":"journal-article","created":{"date-parts":[[2013,4,3]],"date-time":"2013-04-03T06:16:58Z","timestamp":1364969818000},"page":"276-281","source":"Crossref","is-referenced-by-count":14,"title":["Predicting positive food challenges in children sensitised to peanuts\/tree nuts"],"prefix":"10.1111","volume":"24","author":[{"given":"Sian","family":"Ludman","sequence":"first","affiliation":[{"name":"Division of Allergology Immunology and Rheumatology Department of Pediatrics University Hospital Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Ballabeni","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine (IUMSP) University Hospital Center and University of Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe A.","family":"Eigenmann","sequence":"additional","affiliation":[{"name":"Pediatric Allergy Department of Pediatrics University Hospitals Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline","family":"Wassenberg","sequence":"additional","affiliation":[{"name":"Pediatric Allergology Practice Vevey Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00933.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(03)02026-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112031"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(89)90181-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.02978.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.08.039"},{"key":"e_1_2_8_8_1","first-page":"346","article-title":"Committee on Nutrition. 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