{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:11:04Z","timestamp":1790471464671,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,4,11]],"date-time":"2013-04-11T00:00:00Z","timestamp":1365638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The early introduction of fish has been reported to reduce the risk of wheezing disorder in early childhood, while broad\u2010spectrum antibiotics in the first week have been associated with an increased risk. However, it is uncertain whether the effects remain into school age. The aim was to explore these risk factors for doctor\u2010diagnosed asthma at 8\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were obtained from a prospective, longitudinal study of a cohort of children born in western Sweden. The parents answered questionnaires at 6\u00a0months and 1, 4.5 and 8\u00a0years of age. The response rate at 8\u00a0years was 80% of the questionnaires distributed (4051\/5044), that is, 71% of the families entering the study (4051\/5654).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 8\u00a0years, 5.7% reported current doctor\u2010diagnosed asthma. Of these, 65% had atopic asthma and 35% non\u2010atopic asthma. In the multivariate analysis, atopic heredity, male gender and own allergic disease during infancy were risk factors for doctor\u2010diagnosed asthma at 8\u00a0years. In addition, the introduction of fish before the age of 9\u00a0months independently reduced the risk (adjusted OR 0.6; 95% CI 0.4\u20130.96), while broad\u2010spectrum antibiotics in the first week independently increased the risk of current asthma at school age (<jats:styled-content style=\"fixed-case\">aOR<\/jats:styled-content> 2.3; 1.2\u20134.2). Regarding types of asthma, the effects were significant in atopic asthma but not in non\u2010atopic asthma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The early introduction of fish and neonatal antibiotic treatment influence the risk of asthma into school age. The significant effect on atopic asthma is of particular importance, as this phenotype is of major clinical significance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12078","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T02:38:31Z","timestamp":1365734311000},"page":"339-344","source":"Crossref","is-referenced-by-count":55,"title":["Early fish introduction and neonatal antibiotics affect the risk of asthma into school age"],"prefix":"10.1111","volume":"24","author":[{"given":"Emma","family":"Goks\u00f6r","sequence":"first","affiliation":[{"name":"Department of Paediatrics Queen Silvia Children's Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernt","family":"Alm","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Queen Silvia Children's Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Pettersson","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Queen Silvia Children's Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"M\u00f6llborg","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Queen Silvia Children's Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laslo","family":"Erdes","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Queen Silvia Children's Hospital University of Gothenburg Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"\u00c5berg","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Queen Silvia Children's Hospital University of Gothenburg Gothenburg 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