{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:12:20Z","timestamp":1767888740362,"version":"3.49.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T00:00:00Z","timestamp":1370217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Allergy Immunology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There was a lack of convincing evidence supporting the influence of allergy on the adenotonsillar hypertrophy (<jats:styled-content style=\"fixed-case\">ATH<\/jats:styled-content>). We investigated the presence of specific <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>gE (<jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>) in the serum and adenotonsillar tissues in children with <jats:styled-content style=\"fixed-case\">ATH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Pharmacia Immuno<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content> system was used to test <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> against 31 allergens in the serum in 83 children with <jats:styled-content style=\"fixed-case\">ATH<\/jats:styled-content> before adenotonsillectomy. <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> against 15 representative allergens were detected in adenotonsillar tissues from 20 of those children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 51 (61.45%) children had positive serum <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content>. 20 children with <jats:styled-content style=\"fixed-case\">ATH<\/jats:styled-content> had positive <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> to more than two allergens at both tonsils and adenoids, although half of them were serum <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> negative. The percentage of subjects with positive <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> expression in adenoids and tonsils was 50.0% and 42.9%, respectively, among the subjects with positive serum <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> expression. Of subjects with negative serum <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> expression, local <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> was detected in 36.0% of adenoids and 43.8% of tonsils, respectively. The rate of <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> presence in local tissue (adenoids or tonsils) was significantly higher than that seen in the serum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provided evidence that there was an important role for allergic inflammation in the <jats:styled-content style=\"fixed-case\">ATH<\/jats:styled-content>. The inconsistency in <jats:styled-content style=\"fixed-case\">sIgE<\/jats:styled-content> expression between adenotonsillar and serum suggests a role of local atopy in childhood <jats:styled-content style=\"fixed-case\">ATH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pai.12089","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T10:32:08Z","timestamp":1370255528000},"page":"422-426","source":"Crossref","is-referenced-by-count":26,"title":["Local atopy is more relevant than serum s<scp>I<\/scp>g<scp>E<\/scp> in reflecting allergy in childhood adenotonsillar hypertrophy"],"prefix":"10.1111","volume":"24","author":[{"given":"Xiaowen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The First Affiliated Hospital Guangzhou Medical College Guangzhou Guangdong 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